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Tent5c terminal nucleotidyltransferase 5C [ Rattus norvegicus (Norway rat) ]

Gene ID: 310721, updated on 2-Nov-2024

Summary

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Official Symbol
Tent5cprovided by RGD
Official Full Name
terminal nucleotidyltransferase 5Cprovided by RGD
Primary source
RGD:1359446
See related
EnsemblRapid:ENSRNOG00000070242 AllianceGenome:RGD:1359446
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam46c
Summary
Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization and negative regulation of cell differentiation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Orthologous to human TENT5C (terminal nucleotidyltransferase 5C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 891.6), Testes (RPKM 229.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tent5c in Genome Data Viewer
Location:
2q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (190541668..190563902, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (187853026..187875260, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (202797766..202816562, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 17 Neighboring gene WD repeat domain 3 Neighboring gene ganglioside-induced differentiation-associated-protein 2 Neighboring gene uncharacterized LOC120100896 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mannosidase, alpha, class 1A, member 2 Neighboring gene uncharacterized LOC120100606

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Mroczek S, et al. Nat Commun, 2017 Sep 20. PMID 28931820, Free PMC Article
  2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
terminal nucleotidyltransferase 5C
Names
family with sequence similarity 46, member C
protein FAM46C
putative nucleotidyltransferase FAM46C
NP_001014063.1
XP_006233100.1
XP_038958327.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014041.1 → NP_001014063.1  terminal nucleotidyltransferase 5C

    See identical proteins and their annotated locations for NP_001014063.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083570
    UniProtKB/Swiss-Prot
    Q5XIV0
    UniProtKB/TrEMBL
    A0A8L2UJK0, A6K3G4
    Related
    ENSRNOP00000080921.1, ENSRNOT00000103060.2
    Conserved Domains (1) summary
    pfam07984
    Location:17 → 334
    NTP_transf_7; Nucleotidyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    190541668..190563902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102399.2 → XP_038958327.1  terminal nucleotidyltransferase 5C isoform X1

    UniProtKB/TrEMBL
    A0A8L2UJK0
    Conserved Domains (1) summary
    pfam07984
    Location:31 → 348
    NTP_transf_7; Nucleotidyltransferase

  2. XM_006233038.5 → XP_006233100.1  terminal nucleotidyltransferase 5C isoform X2

    See identical proteins and their annotated locations for XP_006233100.1

    UniProtKB/Swiss-Prot
    Q5XIV0
    UniProtKB/TrEMBL
    A0A8L2UJK0, A6K3G4
    Related
    ENSRNOP00000093669.1, ENSRNOT00000116221.2
    Conserved Domains (1) summary
    pfam07984
    Location:17 → 334
    NTP_transf_7; Nucleotidyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIV0.1 GenPept UniProtKB/Swiss-Prot:Q5XIV0

Gene LinkOut

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