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Extl2 exostosin-like glycosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310803, updated on 2-Nov-2024

Summary

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Official Symbol
Extl2provided by RGD
Official Full Name
exostosin-like glycosyltransferase 2provided by RGD
Primary source
RGD:1307684
See related
EnsemblRapid:ENSRNOG00000014323 AllianceGenome:RGD:1307684
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; and manganese ion binding activity. Predicted to be involved in N-acetylglucosamine metabolic process and UDP-N-acetylgalactosamine metabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and nucleoplasm. Orthologous to human EXTL2 (exostosin like glycosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 126.3), Muscle (RPKM 34.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Extl2 in Genome Data Viewer
Location:
2q42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206607106..206631861)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (203922217..203946940)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (218951112..218972576)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 5 Neighboring gene solute carrier family 30 member 7 Neighboring gene uncharacterized LOC120100923 Neighboring gene ribosomal protein L13, pseudogene 18 Neighboring gene ribosomal protein S27a, pseudogene 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. Pedersen LC, et al. J Biol Chem, 2003 Apr 18. PMID 12562774
  2. The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. Kitagawa H, et al. J Biol Chem, 1999 May 14. PMID 10318803
  3. The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. McCormick C, et al. Proc Natl Acad Sci U S A, 2000 Jan 18. PMID 10639137, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-1,4-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-N-acetylgalactosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exostosin-like 2
Names
exostoses (multiple)-like 2
exostoses-like 2
exotoses (multiple)-like 2
NP_001094174.1
XP_006233277.1
XP_006233278.1
XP_038958355.1
XP_038958356.1
XP_063138002.1
XP_063138003.1
XP_063138004.1
XP_063138005.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100704.1 → NP_001094174.1  exostosin-like 2

    See identical proteins and their annotated locations for NP_001094174.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162014
    UniProtKB/TrEMBL
    B1WC59, F7F8T0
    Conserved Domains (1) summary
    pfam09258
    Location:66 → 312
    Glyco_transf_64; Glycosyl transferase family 64 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    206607106..206631861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233216.5 → XP_006233278.1  exostosin-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006233278.1

    UniProtKB/TrEMBL
    B1WC59, F7F8T0
    Related
    ENSRNOP00000019190.5, ENSRNOT00000019190.7
    Conserved Domains (1) summary
    pfam09258
    Location:66 → 312
    Glyco_transf_64; Glycosyl transferase family 64 domain

  2. XM_063281935.1 → XP_063138005.1  exostosin-like 2 isoform X3

  3. XM_039102428.2 → XP_038958356.1  exostosin-like 2 isoform X2

    UniProtKB/TrEMBL
    F7F8T0
    Conserved Domains (1) summary
    pfam09258
    Location:49 → 279
    Glyco_transf_64; Glycosyl transferase family 64 domain

  4. XM_063281933.1 → XP_063138003.1  exostosin-like 2 isoform X3

  5. XM_039102427.2 → XP_038958355.1  exostosin-like 2 isoform X2

    UniProtKB/TrEMBL
    F7F8T0
    Conserved Domains (1) summary
    pfam09258
    Location:49 → 279
    Glyco_transf_64; Glycosyl transferase family 64 domain

  6. XM_063281934.1 → XP_063138004.1  exostosin-like 2 isoform X3

  7. XM_063281932.1 → XP_063138002.1  exostosin-like 2 isoform X2

  8. XM_006233215.5 → XP_006233277.1  exostosin-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006233277.1

    UniProtKB/TrEMBL
    B1WC59, F7F8T0
    Conserved Domains (1) summary
    pfam09258
    Location:66 → 312
    Glyco_transf_64; Glycosyl transferase family 64 domain
Nucleotide Protein Strain
Heading Accession and Version

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