U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdc14a cell division cycle 14A [ Rattus norvegicus (Norway rat) ]

Gene ID: 310806, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Cdc14aprovided by RGD
Official Full Name
cell division cycle 14Aprovided by RGD
Primary source
RGD:1304649
See related
EnsemblRapid:ENSRNOG00000014515 AllianceGenome:RGD:1304649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
The protein encoded by this gene is a dual-specificity phosphatase that preferentially dephosphorylates cyclin dependent kinase substrates to regulate the cell cycle. In human cell lines, this protein localizes to interphase chromosomes, and depletion of the transcript results in centrosome separation and cytokinesis defects. In mouse, the protein localizes to the nucleus of prophase I arrested oocytes and then becomes dispersed in meiotically competent oocytes. Knockdown of the protein delays exit from metaphase I and results in eggs with chromosomal abnormalities and elevated aneuploidy, demonstrating a function in regulation of meiosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Biased expression in Spleen (RPKM 86.9), Lung (RPKM 86.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cdc14a in Genome Data Viewer
Location:
2q42
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206910475..207070537, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204225540..204380927, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219302577..219458345, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485676 Neighboring gene G-protein coupled receptor 88 Neighboring gene uncharacterized LOC134485677 Neighboring gene uncharacterized LOC120100925 Neighboring gene uncharacterized LOC134485678 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene dihydrolipoamide branched chain transacylase E2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The CDC14A phosphatase regulates oocyte maturation in mouse. Schindler K, et al. Cell Cycle, 2009 Apr 1. PMID 19270517, Free PMC Article
  2. Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. Sanchez M, et al. J Biol Chem, 2006 Aug 11. PMID 16760464
  3. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Mailand N, et al. Nat Cell Biol, 2002 Apr. PMID 11901424
  4. CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Imtiaz A, et al. Hum Mol Genet, 2018 Mar 1. PMID 29293958, Free PMC Article
  5. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, et al. Chem Rev, 2013 Nov 13. PMID 23837720

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinociliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in kinocilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stereocilium tip ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase CDC14A
Names
CDC14 cell division cycle 14 homolog A
NP_001101188.2
NP_001128328.1
XP_008759682.1
XP_017446421.1
XP_017446422.1
XP_063138006.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107718.2 → NP_001101188.2  dual specificity protein phosphatase CDC14A isoform 2

    See identical proteins and their annotated locations for NP_001101188.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC161876
    UniProtKB/TrEMBL
    A0A8I6B415, B1WBT1, D4ABH9
    Conserved Domains (2) summary
    cd14499
    Location:163 → 336
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    cd17657
    Location:10 → 154
    CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

  2. NM_001134856.1 → NP_001128328.1  dual specificity protein phosphatase CDC14A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. It encodes isoform 1.
    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZMT6, E9PSZ9
    Related
    ENSRNOP00000061448.2, ENSRNOT00000064735.6
    Conserved Domains (3) summary
    COG2453
    Location:175 → 329
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17 → 152
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:187 → 326
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    206910475..207070537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761460.4 → XP_008759682.1  dual specificity protein phosphatase CDC14A isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZMT6
    Related
    ENSRNOP00000096339.2, ENSRNOT00000112422.2
    Conserved Domains (3) summary
    COG2453
    Location:190 → 344
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    pfam14671
    Location:17 → 167
    DSPn; Dual specificity protein phosphatase, N-terminal half
    cl21483
    Location:202 → 341
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_063281936.1 → XP_063138006.1  dual specificity protein phosphatase CDC14A isoform X3

  3. XM_017590932.3 → XP_017446421.1  dual specificity protein phosphatase CDC14A isoform X1

    UniProtKB/TrEMBL
    A0A8I6B415

  4. XM_017590933.3 → XP_017446422.1  dual specificity protein phosphatase CDC14A isoform X3

    UniProtKB/TrEMBL
    A0A8I6B415
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools