Ptbp2 polypyrimidine tract binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptbp2provided by RGD
Official Full Name: polypyrimidine tract binding protein 2provided by RGD
Primary source: RGD:1359267
See related: EnsemblRapid:ENSRNOG00000010827 AllianceGenome:RGD:1359267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptb2; PTBLP; PTBLP-L; PTBLP-S
Summary: Predicted to enable mRNA binding activity. Involved in cerebellum development; negative regulation of RNA splicing; and spinal cord development. Located in growth cone and neuronal cell body. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 271.8), Thymus (RPKM 137.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (210497610..210558497, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (207812659..207874019, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (223261444..223323075, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown.
Title: HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.

Submit: New GeneRIF Correction

General gene information

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Markers

Ptbp2 (e-PCR), detects polymorphism
- UniSTS:479020

RH143836 (e-PCR)
- UniSTS:233082

Ptbp2 (e-PCR), detects polymorphism
- UniSTS:546967

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA splice site recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polypyrimidine tract-binding protein 2

Names: PTB-like protein; neural polypyrimidine tract-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.