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Manba mannosidase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 310864, updated on 2-Nov-2024

Summary

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Official Symbol
Manbaprovided by RGD
Official Full Name
mannosidase betaprovided by RGD
Primary source
RGD:1305785
See related
EnsemblRapid:ENSRNOG00000052247 AllianceGenome:RGD:1305785
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables D-mannose binding activity and beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process and oligosaccharide catabolic process. Predicted to be located in extracellular space. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 334.2), Liver (RPKM 104.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Manba in Genome Data Viewer
Location:
2q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (226583968..226676520)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223910432..224002988)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240668213..240760264)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member B1 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear factor kappa B subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Beta-mannosidosis mice: a model for the human lysosomal storage disease. Zhu M, et al. Hum Mol Genet, 2006 Feb 1. PMID 16377659
  2. The structure of mammalian β-mannosidase provides insight into β-mannosidosis and nystagmus. Gytz H, et al. FEBS J, 2019 Apr. PMID 30552791
  3. A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3. Lundin LG. Biochem Genet, 1987 Aug. PMID 3447593
  4. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, et al. J Biol Chem, 1996 Aug 9. PMID 8702598
  5. Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Boonen M, et al. Mol Biol Cell, 2009 Oct. PMID 19710420, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC116230, MGC125196

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-mannose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-mannosidase
Names
lysosomal beta A mannosidase
mannanase
mannase
mannosidase beta A
mannosidase, beta A, lysosomal
NP_001026825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031655.2 → NP_001026825.1  beta-mannosidase precursor

    See identical proteins and their annotated locations for NP_001026825.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q2NKP5, Q4FZV0
    UniProtKB/TrEMBL
    A6HVY3
    Related
    ENSRNOP00000072765.1, ENSRNOT00000087371.3
    Conserved Domains (3) summary
    COG3250
    Location:24 → 694
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
    pfam02837
    Location:80 → 136
    Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
    cl23725
    Location:397 → 568
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    226583968..226676520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZV0.1 GenPept UniProtKB/Swiss-Prot:Q4FZV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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