Mttp microsomal triglyceride transfer protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mttpprovided by RGD
Official Full Name: microsomal triglyceride transfer proteinprovided by RGD
Primary source: RGD:1308388
See related: EnsemblRapid:ENSRNOG00000010655 AllianceGenome:RGD:1308388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MTP
Summary: Enables apolipoprotein binding activity and lipid transfer activity. Involved in several processes, including cholesterol homeostasis; lipoprotein metabolic process; and response to calcium ion. Located in basolateral plasma membrane; cell projection membrane; and vesicle. Biomarker of familial hyperlipidemia. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 934.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229286501..229327650, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226613090..226654239, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243366181..243407608, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Mttp content of liver microsomes can be altered by dietary factors; here, Mttp is up-regulated in liver microsomes of obese rats with dietary supplementation of the fatty acid alpha-linolenic acid; animal physical conditioning (exercise) appears to up-regulate Mttp in liver microsomes in an independent manner.
Title: α-Linolenic acid supplementation and exercise training reveal independent and additive responses on hepatic lipid accumulation in obese rats.
Coordinated up-regulation of Mttp, Apob, Hnf1a, Hnf4a, Fasn, Gpam and Dgat (1 and 2) gene expressions may contribute to the increase in circulating and liver concentrations of TAGs after lipectomy in an experimental rat model
Title: Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia.
Tau supplementation prevented obesity and hepatic TG deposition by upregulating MTP mRNA, ameliorating hepatic lipid efflux, and consequently enhancing PPAR-alpha which increases lipid oxidation through ACO and CPT-1a gene expressions.
Title: Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.
Octreotide intervention down-regulated expression of apoB mRNA and apoB48 protein, as well as MTP mRNA and proteins. ApoAIV mRNA was not significantly different between obese and octreotide-treated rats.
Title: Octreotide promotes weight loss via suppression of intestinal MTP and apoB48 expression in diet-induced obesity rats.
As the XBP-1/PDI/MTP axis has been suggested to represent a significant lipogenic mechanism in the liver response to ER stress, our data indicate that hypertriglyceridemia and liver steatosis occurring MSG rats are associated with increased MTP.
Title: Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.
Retinal pigment epithelial cells cells express genes encoding apolipoproteins and microsomal triglyceride transfer protein.
Title: [Gene expression of apolipoprotein and lipids synthesis and secretion in RPE-J cells].
Estrogen withdrawal resulted in lower VLDL-TG production and lower expression of hepatic MTP.
Title: Hepatic VLDL-TG production and MTP gene expression are decreased in ovariectomized rats: effects of exercise training.
These data indicate that DNA methylation of the microsomal triglyceride transfer protein promoter likely contributes to its downregulation during high-fat diet-induced nonalcoholic fatty liver disease.
Title: Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats.
A factor(s) other than microsomal triglyceride transfer protein mediates the formation of the phospholipid-rich primordial apoB:1000-containing initiation complex.
Title: Apolipoprotein B-containing lipoprotein assembly in microsomal triglyceride transfer protein-deficient McA-RH7777 cells.
High levels of Ca(2+) cause hypertriglyceridemia through the elevation of MTP activity.
Title: The opposite correlation between calcium ion and cyclic-AMP regarding the activation of microsomal triglyceride transfer protein in rat liver.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables apolipoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ceramide 1-phosphate transfer activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylcholine transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylethanolamine transfer activity	ISO Inferred from Sequence Orthology more info
enables phospholipid transfer activity	ISO Inferred from Sequence Orthology more info
enables phospholipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables triglyceride transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride transfer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide 1-phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoprotein metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipoprotein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in sterol transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: microsomal triglyceride transfer protein large subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.