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Gbp4 guanylate binding protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310917, updated on 2-Nov-2024

Summary

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Symbol
Gbp4provided by RGD
Full Name
guanylate binding protein 4provided by RGD
Primary source
RGD:1310579
See related
EnsemblRapid:ENSRNOG00000028768 AllianceGenome:RGD:1310579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of defense response. Predicted to act upstream of or within adhesion of symbiont to host and cellular response to interferon-beta. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle. Orthologous to several human genes including GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 113.0), Thymus (RPKM 35.5) and 8 other tissues See more
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Genomic context

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See Gbp4 in Genome Data Viewer
Location:
2q44
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (233978163..233992124)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (231304910..231318883)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248249232..248263104)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 5 Neighboring gene guanylate binding protein 7 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC134485987

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
  2. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in cytolysis in another organism ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to protozoan ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanylate-binding protein 4
Names
guanylate nucleotide binding protein 3
guanylate nucleotide binding protein 4
guanylate-binding protein 4-like
NP_001292190.1
XP_006233486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305261.1 → NP_001292190.1  guanylate-binding protein 4

    See identical proteins and their annotated locations for NP_001292190.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HW65, A6HW67, D3ZQL3
    Related
    ENSRNOP00000022648.3, ENSRNOT00000022648.7
    Conserved Domains (3) summary
    pfam02841
    Location:277 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:12 → 275
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:283 → 573
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    233978163..233992124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233424.5 → XP_006233486.1  guanylate-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233486.1

    UniProtKB/TrEMBL
    A6HW65
    Conserved Domains (3) summary
    pfam02841
    Location:269 → 558
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:12 → 271
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:269 → 558
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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