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Plekhg5 pleckstrin homology and RhoGEF domain containing G5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310999, updated on 2-Nov-2024

Summary

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Official Symbol
Plekhg5provided by RGD
Official Full Name
pleckstrin homology and RhoGEF domain containing G5provided by RGD
Primary source
RGD:1303132
See related
EnsemblRapid:ENSRNOG00000022694 AllianceGenome:RGD:1303132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tech
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of canonical NF-kappaB signal transduction; and regulation protein catabolic process at presynapse. Predicted to be located in several cellular components, including cell-cell junction; lamellipodium; and presynapse. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 54.7), Adrenal (RPKM 47.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekhg5 in Genome Data Viewer
Location:
5q36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167860730..167904229)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162577999..162621518)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169244778..169288310)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 1 Neighboring gene nucleolar protein 9 Neighboring gene TNF receptor superfamily member 25 Neighboring gene espin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension. Cario-Toumaniantz C, et al. Am J Physiol Cell Physiol, 2012 May 1. PMID 22322975
  2. Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons. Marx R, et al. J Neurochem, 2005 Feb. PMID 15686487
  3. The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1. Estévez MA, et al. J Neurochem, 2008 Aug. PMID 18537874, Free PMC Article
  4. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Lüningschrör P, et al. Nat Commun, 2017 Oct 30. PMID 29084947, Free PMC Article
  5. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Liu M, et al. Mol Biol Cell, 2006 Apr. PMID 16467373, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This work thus identifies a group of RhoA-GEFs that controls RhoA and RhoA-dependent functions in vascular smooth muscle cells
    Title: RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension.
  2. Tech regulates RhoA signaling pathways in developing and mature forebrain neurons.
    Title: Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation protein catabolic process at presynapse ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family G member 5
Names
PH domain-containing family G member 5
neuronal RhoA GEF protein
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
transcript highly enriched in cortex and hippocampus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415855.1 → NP_001402784.1  pleckstrin homology domain-containing family G member 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AJ37
    Related
    ENSRNOP00000093604.2, ENSRNOT00000107438.2

  2. NM_001415856.1 → NP_001402785.1  pleckstrin homology domain-containing family G member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K1M4
    Related
    ENSRNOP00000104105.1, ENSRNOT00000139516.1

  3. NM_201272.2 → NP_958429.1  pleckstrin homology domain-containing family G member 5 isoform 3

    See identical proteins and their annotated locations for NP_958429.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q6RFZ7
    UniProtKB/TrEMBL
    A0A0G2K8X8
    Related
    ENSRNOP00000059729.1, ENSRNOT00000064841.4
    Conserved Domains (4) summary
    smart00325
    Location:376 → 562
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13244
    Location:619 → 717
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    cd17068
    Location:110 → 184
    RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
    pfam03154
    Location:851 → 1015
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    167860730..167904229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109738.2 → XP_038965666.1  pleckstrin homology domain-containing family G member 5 isoform X3

    UniProtKB/Swiss-Prot
    Q6RFZ7
    UniProtKB/TrEMBL
    A0A0G2K8X8
    Conserved Domains (4) summary
    smart00325
    Location:376 → 562
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13244
    Location:619 → 717
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    cd17068
    Location:110 → 184
    RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
    pfam03154
    Location:851 → 1015
    Atrophin-1; Atrophin-1 family

  2. XM_039109735.2 → XP_038965663.1  pleckstrin homology domain-containing family G member 5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8X8, A0A8I6A5Z3
    Related
    ENSRNOP00000088309.1, ENSRNOT00000118143.2
    Conserved Domains (4) summary
    smart00325
    Location:438 → 624
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13244
    Location:681 → 779
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    cd17068
    Location:172 → 246
    RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
    pfam03154
    Location:913 → 1077
    Atrophin-1; Atrophin-1 family

  3. XM_039109734.2 → XP_038965662.1  pleckstrin homology domain-containing family G member 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8X8
    Conserved Domains (4) summary
    smart00325
    Location:394 → 580
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13244
    Location:637 → 735
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    cd17068
    Location:128 → 202
    RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
    pfam03154
    Location:869 → 1033
    Atrophin-1; Atrophin-1 family

  4. XM_039109739.2 → XP_038965667.1  pleckstrin homology domain-containing family G member 5 isoform X3

    UniProtKB/Swiss-Prot
    Q6RFZ7
    UniProtKB/TrEMBL
    A0A0G2K8X8
    Conserved Domains (4) summary
    smart00325
    Location:376 → 562
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13244
    Location:619 → 717
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    cd17068
    Location:110 → 184
    RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
    pfam03154
    Location:851 → 1015
    Atrophin-1; Atrophin-1 family

  5. XM_039109740.2 → XP_038965668.1  pleckstrin homology domain-containing family G member 5 isoform X4

    Conserved Domains (3) summary
    cd13244
    Location:182 → 280
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:20 → 125
    RhoGEF; RhoGEF domain
    pfam03154
    Location:414 → 578
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RFZ7.1 GenPept UniProtKB/Swiss-Prot:Q6RFZ7

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