U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubr3 ubiquitin protein ligase E3 component n-recognin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311115, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ubr3provided by RGD
Official Full Name
ubiquitin protein ligase E3 component n-recognin 3provided by RGD
Primary source
RGD:1565257
See related
EnsemblRapid:ENSRNOG00000008616 AllianceGenome:RGD:1565257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565257
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and positive regulation of protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human UBR3 (ubiquitin protein ligase E3 component n-recognin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 341.4), Heart (RPKM 226.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ubr3 in Genome Data Viewer
Location:
3q21-q22
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75057615..75214581)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54649803..54806779)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56125927..56283908)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 5 Neighboring gene uncharacterized LOC134486377 Neighboring gene myosin IIIB Neighboring gene uncharacterized LOC134486378

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Modulation of Ca(2+)-induced Ca(2+) release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes. Ma XE, et al. Channels (Austin), 2020 Dec. PMID 32988261, Free PMC Article
  2. Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6. Zhao C, et al. J Cell Mol Med, 2015 Sep. PMID 26059563, Free PMC Article
  3. Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. Tasaki T, et al. J Biol Chem, 2007 Jun 22. PMID 17462990
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modulation of Ca(2+)-induced Ca(2+) release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes.
    Title: Modulation of Ca(2+)-induced Ca(2+) release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes.
  2. UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway.
    Title: Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within olfactory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within suckling behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase UBR3
NP_001128022.2
XP_038960775.1
XP_038960776.1
XP_038960777.1
XP_038960778.1
XP_038960779.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134550.3 → NP_001128022.2  E3 ubiquitin-protein ligase UBR3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4A7F0
    Conserved Domains (2) summary
    cd16483
    Location:1231 → 1369
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    pfam02207
    Location:116 → 184
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    75057615..75214581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104847.2 → XP_038960775.1  E3 ubiquitin-protein ligase UBR3 isoform X1

    UniProtKB/TrEMBL
    D4A7F0
    Conserved Domains (3) summary
    cd16483
    Location:1242 → 1380
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    pfam02207
    Location:117 → 184
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam18995
    Location:1438 → 1884
    PRT6_C; Proteolysis_6 C-terminal

  2. XM_039104849.2 → XP_038960777.1  E3 ubiquitin-protein ligase UBR3 isoform X3

    UniProtKB/TrEMBL
    D4A7F0
    Conserved Domains (3) summary
    cd16483
    Location:1242 → 1380
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    pfam02207
    Location:117 → 184
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam18995
    Location:1434 → 1880
    PRT6_C; Proteolysis_6 C-terminal

  3. XM_039104850.2 → XP_038960778.1  E3 ubiquitin-protein ligase UBR3 isoform X4

    UniProtKB/TrEMBL
    D4A7F0
    Related
    ENSRNOP00000011380.9, ENSRNOT00000011380.10
    Conserved Domains (3) summary
    cd16483
    Location:1231 → 1369
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    pfam02207
    Location:117 → 184
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam18995
    Location:1423 → 1869
    PRT6_C; Proteolysis_6 C-terminal

  4. XM_039104848.2 → XP_038960776.1  E3 ubiquitin-protein ligase UBR3 isoform X2

    UniProtKB/TrEMBL
    D4A7F0
    Conserved Domains (3) summary
    cd16483
    Location:1241 → 1379
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    pfam02207
    Location:117 → 184
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam18995
    Location:1437 → 1883
    PRT6_C; Proteolysis_6 C-terminal

  5. XM_039104851.2 → XP_038960779.1  E3 ubiquitin-protein ligase UBR3 isoform X5

    UniProtKB/TrEMBL
    D4A7F0
    Conserved Domains (3) summary
    cd16483
    Location:1230 → 1368
    RING-H2_UBR3; RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
    pfam02207
    Location:117 → 184
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
    pfam18995
    Location:1426 → 1872
    PRT6_C; Proteolysis_6 C-terminal

RNA

  1. XR_005501856.2 RNA Sequence

  2. XR_005501857.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.