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Tlk1 tousled-like kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311118, updated on 9-Jul-2024

Summary

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Symbol
Tlk1provided by RGD
Full Name
tousled-like kinase 1provided by RGD
Primary source
RGD:1310370
See related
Ensembl:ENSRNOG00000009300 AllianceGenome:RGD:1310370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; protein phosphorylation; and regulation of chromatin assembly or disassembly. Predicted to be located in nucleoplasm. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 172.8), Spleen (RPKM 164.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tlk1 in Genome Data Viewer
Location:
3q22
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75928303..76035246, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55520559..55627580, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57012738..57376336, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486102 Neighboring gene uncharacterized LOC134486101 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene uncharacterized LOC120101562 Neighboring gene uncharacterized LOC134486287 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. Cabaniols JP, et al. Mol Biol Cell, 1999 Dec. PMID 10588641, Free PMC Article
  2. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. Groth A, et al. EMBO J, 2003 Apr 1. PMID 12660173, Free PMC Article
  3. Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. Silljé HH, et al. EMBO J, 1999 Oct 15. PMID 10523312, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase tousled-like 1
NP_001381947.1
NP_001381948.1
XP_008760119.1
XP_008760121.1
XP_038960783.1
XP_038960784.1
XP_063139694.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395018.1 → NP_001381947.1  serine/threonine-protein kinase tousled-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K920, A0A8I6AQ02
    Related
    ENSRNOP00000068174.3, ENSRNOT00000076281.4
    Conserved Domains (1) summary
    cd14040
    Location:449 → 747
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  2. NM_001395019.1 → NP_001381948.1  serine/threonine-protein kinase tousled-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A096MJL4
    Conserved Domains (1) summary
    cd14040
    Location:401 → 699
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    75928303..76035246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104855.2 → XP_038960783.1  serine/threonine-protein kinase tousled-like 1 isoform X2

    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  2. XM_008761897.4 → XP_008760119.1  serine/threonine-protein kinase tousled-like 1 isoform X1

    See identical proteins and their annotated locations for XP_008760119.1

    UniProtKB/TrEMBL
    A0A096MJL4
    Conserved Domains (1) summary
    cd14040
    Location:401 → 699
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  3. XM_008761899.4 → XP_008760121.1  serine/threonine-protein kinase tousled-like 1 isoform X1

    See identical proteins and their annotated locations for XP_008760121.1

    UniProtKB/TrEMBL
    A0A096MJL4
    Conserved Domains (1) summary
    cd14040
    Location:401 → 699
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

  4. XM_063283624.1 → XP_063139694.1  serine/threonine-protein kinase tousled-like 1 isoform X2

  5. XM_039104856.2 → XP_038960784.1  serine/threonine-protein kinase tousled-like 1 isoform X2

    Conserved Domains (1) summary
    cd14040
    Location:232 → 530
    STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

RNA

  1. XR_005501858.2 RNA Sequence

    Related
    ENSRNOT00000064203.4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107734.1: Suppressed sequence

    Description
    NM_001107734.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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