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Osbpl6 oxysterol binding protein-like 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311129, updated on 2-Nov-2024

Summary

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Official Symbol
Osbpl6provided by RGD
Official Full Name
oxysterol binding protein-like 6provided by RGD
Primary source
RGD:1308887
See related
EnsemblRapid:ENSRNOG00000010812 AllianceGenome:RGD:1308887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cholesterol binding activity. Predicted to be involved in regulation of cholesterol transport. Predicted to be located in early endosome membrane and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Orthologous to human OSBPL6 (oxysterol binding protein like 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 105.8), Heart (RPKM 101.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Osbpl6 in Genome Data Viewer
Location:
3q24
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (81751020..81948186)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (61343776..61541170)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (63257646..63455105)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 11A Neighboring gene acidic nuclear phosphoprotein 32 family member A, pseudogene 1 Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene uncharacterized LOC134486118 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene pejvakin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Ouimet M, et al. Arterioscler Thromb Vasc Biol, 2016 May. PMID 26941018, Free PMC Article
  2. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. Lehto M, et al. Cell Tissue Res, 2004 Jan. PMID 14593528
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107735.2 → NP_001101205.1  oxysterol-binding protein-related protein 6 isoform d

    See identical proteins and their annotated locations for NP_001101205.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HMH4, A6HMH5
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:570 → 911
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001431697.1 → NP_001418626.1  oxysterol-binding protein-related protein 6 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001431698.1 → NP_001418627.1  oxysterol-binding protein-related protein 6 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4A0F3

  4. NM_001431699.1 → NP_001418628.1  oxysterol-binding protein-related protein 6 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZY24

  5. NM_001431700.1 → NP_001418629.1  oxysterol-binding protein-related protein 6 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HMH5

  6. NM_001431701.1 → NP_001418630.1  oxysterol-binding protein-related protein 6 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JZR1

  7. NM_001431702.1 → NP_001418631.1  oxysterol-binding protein-related protein 6 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  8. NM_001431703.1 → NP_001418632.1  oxysterol-binding protein-related protein 6 isoform g

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AMZ3

  9. NM_001431704.1 → NP_001418633.1  oxysterol-binding protein-related protein 6 isoform h

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  10. NM_001431705.1 → NP_001418634.1  oxysterol-binding protein-related protein 6 isoform i precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  11. NM_001431706.1 → NP_001418635.1  oxysterol-binding protein-related protein 6 isoform j

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  12. NM_001431707.1 → NP_001418636.1  oxysterol-binding protein-related protein 6 isoform k precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  13. NM_001431708.1 → NP_001418637.1  oxysterol-binding protein-related protein 6 isoform l

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    81751020..81948186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591693.3 → XP_017447182.1  oxysterol-binding protein-related protein 6 isoform X1

    Related
    ENSRNOP00000059467.2, ENSRNOT00000068199.4
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:603 → 944
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_017591695.3 → XP_017447184.1  oxysterol-binding protein-related protein 6 isoform X2

    Related
    ENSRNOP00000112175.1, ENSRNOT00000151334.1
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:595 → 936
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_039104857.2 → XP_038960785.1  oxysterol-binding protein-related protein 6 isoform X8

    UniProtKB/TrEMBL
    A6HMH4
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:559 → 907
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_017591696.3 → XP_017447185.1  oxysterol-binding protein-related protein 6 isoform X3

    UniProtKB/TrEMBL
    A6HMH4
    Related
    ENSRNOP00000110453.1, ENSRNOT00000125272.1
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:578 → 919
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_017591698.3 → XP_017447187.1  oxysterol-binding protein-related protein 6 isoform X6

    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:570 → 911
    Oxysterol_BP; Oxysterol-binding protein

  6. XM_039104858.2 → XP_038960786.1  oxysterol-binding protein-related protein 6 isoform X12

    UniProtKB/TrEMBL
    A6HMH4
    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:534 → 882
    Oxysterol_BP; Oxysterol-binding protein

  7. XM_017591697.3 → XP_017447186.1  oxysterol-binding protein-related protein 6 isoform X5

    UniProtKB/TrEMBL
    A6HMH4
    Related
    ENSRNOP00000071146.3, ENSRNOT00000091211.3
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:572 → 913
    Oxysterol_BP; Oxysterol-binding protein

  8. XM_008761904.4 → XP_008760126.1  oxysterol-binding protein-related protein 6 isoform X7

    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:564 → 905
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_008761905.4 → XP_008760127.1  oxysterol-binding protein-related protein 6 isoform X10

    UniProtKB/TrEMBL
    A6HMH4
    Related
    ENSRNOP00000095383.2, ENSRNOT00000111872.2
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:547 → 888
    Oxysterol_BP; Oxysterol-binding protein

  10. XM_008761906.4 → XP_008760128.1  oxysterol-binding protein-related protein 6 isoform X11

    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:539 → 880
    Oxysterol_BP; Oxysterol-binding protein

  11. XM_063283627.1 → XP_063139697.1  oxysterol-binding protein-related protein 6 isoform X13

    UniProtKB/TrEMBL
    A0A8I6A0D2
    Related
    ENSRNOP00000085530.1, ENSRNOT00000109671.2

  12. XM_008761907.3 → XP_008760129.1  oxysterol-binding protein-related protein 6 isoform X14

    Conserved Domains (2) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain

  13. XM_063283628.1 → XP_063139698.1  oxysterol-binding protein-related protein 6 isoform X15

  14. XM_063283630.1 → XP_063139700.1  oxysterol-binding protein-related protein 6 isoform X17

  15. XM_063283631.1 → XP_063139701.1  oxysterol-binding protein-related protein 6 isoform X18

  16. XM_063283633.1 → XP_063139703.1  oxysterol-binding protein-related protein 6 isoform X20

  17. XM_063283634.1 → XP_063139704.1  oxysterol-binding protein-related protein 6 isoform X21

  18. XM_017591694.3 → XP_017447183.1  oxysterol-binding protein-related protein 6 isoform X1

    UniProtKB/TrEMBL
    A6HMH4, D4A0F3
    Conserved Domains (3) summary
    cd13287
    Location:66 → 188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:89 → 177
    PH; PH domain
    pfam01237
    Location:603 → 944
    Oxysterol_BP; Oxysterol-binding protein

  19. XM_063283629.1 → XP_063139699.1  oxysterol-binding protein-related protein 6 isoform X16

  20. XM_063283632.1 → XP_063139702.1  oxysterol-binding protein-related protein 6 isoform X19

  21. XM_063283625.1 → XP_063139695.1  oxysterol-binding protein-related protein 6 isoform X4

    Related
    ENSRNOP00000083910.1, ENSRNOT00000112703.2

  22. XM_063283626.1 → XP_063139696.1  oxysterol-binding protein-related protein 6 isoform X9

Nucleotide Protein Strain
Heading Accession and Version

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