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Slc35c1 solute carrier family 35 member C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311204, updated on 17-Aug-2024

Summary

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Official Symbol
Slc35c1provided by RGD
Official Full Name
solute carrier family 35 member C1provided by RGD
Primary source
RGD:1309463
See related
EnsemblRapid:ENSRNOG00000007732 AllianceGenome:RGD:1309463
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GDP-fucose transmembrane transporter activity and antiporter activity. Predicted to be involved in GDP-fucose import into Golgi lumen and protein O-linked fucosylation. Predicted to act upstream of or within lipid glycosylation and negative regulation of Notch signaling pathway. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIc. Orthologous to human SLC35C1 (solute carrier family 35 member C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 45.2), Kidney (RPKM 43.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc35c1 in Genome Data Viewer
Location:
3q24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98877413..98887411, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78421925..78429603, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81361080..81369010, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene Frey regulator of sperm-oocyte fusion 1 Neighboring gene cryptochrome circadian regulator 2 Neighboring gene uncharacterized LOC102546693 Neighboring gene uncharacterized LOC120101599 Neighboring gene uncharacterized LOC108350417

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Lübke T, et al. Nat Genet, 2001 May. PMID 11326280
  2. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. Lu L, et al. J Biol Chem, 2010 Nov 12. PMID 20837470, Free PMC Article
  3. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. Rabionet M, et al. J Biol Chem, 2008 May 9. PMID 18308723, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP-fucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-fucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GDP-fucose import into Golgi lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-fucose import into Golgi lumen ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lipid glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GDP-fucose transporter 1
Names
solute carrier family 35 (GDP-fucose transporter), member C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107748.1 → NP_001101218.1  GDP-fucose transporter 1

    See identical proteins and their annotated locations for NP_001101218.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    A6HNH7, D3ZWW0
    Related
    ENSRNOP00000059968.1, ENSRNOT00000067509.3
    Conserved Domains (1) summary
    pfam03151
    Location:38 → 302
    TPT; Triose-phosphate Transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    98877413..98887411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234568.4 → XP_006234630.1  GDP-fucose transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006234630.1

    UniProtKB/TrEMBL
    A6HNH8
    Conserved Domains (1) summary
    cl26744
    Location:25 → 289
    TPT; Triose-phosphate Transporter family

  2. XM_008762026.3 → XP_008760248.1  GDP-fucose transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_008760248.1

    UniProtKB/TrEMBL
    A6HNH8
    Conserved Domains (1) summary
    cl26744
    Location:25 → 289
    TPT; Triose-phosphate Transporter family

  3. XM_039104908.2 → XP_038960836.1  GDP-fucose transporter 1 isoform X1

    UniProtKB/TrEMBL
    A6HNH8
    Conserved Domains (1) summary
    cl26744
    Location:25 → 289
    TPT; Triose-phosphate Transporter family
Nucleotide Protein Strain
Heading Accession and Version

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