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Ano3 anoctamin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311287, updated on 10-Jul-2024

Summary

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Official Symbol
Ano3provided by RGD
Official Full Name
anoctamin 3provided by RGD
Primary source
RGD:1308873
See related
EnsemblRapid:ENSRNOG00000004731 AllianceGenome:RGD:1308873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem16c
Summary
Predicted to enable intracellular calcium activated chloride channel activity and phospholipid scramblase activity. Involved in detection of mechanical stimulus and detection of temperature stimulus. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dystonia 24. Orthologous to human ANO3 (anoctamin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 215.8) See more
Orthologs
human mouse all
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Genomic context

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See Ano3 in Genome Data Viewer
Location:
3q34
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (117690242..118004695, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (97235671..97550090, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (101843516..102203368, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fin bud initiation factor homolog Neighboring gene solute carrier family 5 member 12 Neighboring gene ribosomal protein L19, pseudogene 1 Neighboring gene mucin 15, cell surface associated Neighboring gene prohibitin-2-like Neighboring gene POTE ankyrin domain family member 1 Neighboring gene olfactory receptor family 4 subfamily F member 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Wang TA, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972431, Free PMC Article
  2. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Huang F, et al. Nat Neurosci, 2013 Sep. PMID 23872594, Free PMC Article
  3. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Scudieri P, et al. Exp Physiol, 2012 Feb. PMID 21984732
  4. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
    Title: TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
  2. This study thus reveals that TMEM16C enhances K(Na) channel activity in DRG neurons and regulates the processing of pain messages.
    Title: TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium activated galactosylceramide scrambling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within plasma membrane phospholipid scrambling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anoctamin-3
Names
transmembrane protein 16C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430402.1 → NP_001417331.1  anoctamin-3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    F1M0A0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    117690242..118004695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106460.2 → XP_038962388.1  anoctamin-3 isoform X1

    Related
    ENSRNOP00000006349.7, ENSRNOT00000006349.8
    Conserved Domains (2) summary
    pfam04547
    Location:384 → 949
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:157 → 381
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  2. XM_039106461.2 → XP_038962389.1  anoctamin-3 isoform X2

    Conserved Domains (2) summary
    pfam04547
    Location:238 → 803
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:11 → 235
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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