U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nusap1 nucleolar and spindle associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311336, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
Nusap1provided by RGD
Official Full Name
nucleolar and spindle associated protein 1provided by RGD
Primary source
RGD:1305764
See related
Ensembl:ENSRNOG00000004921 AllianceGenome:RGD:1305764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Predicted to be located in cytoplasm and microtubule. Predicted to be active in mitotic spindle and nucleolus. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 251.2), Spleen (RPKM 117.8) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nusap1 in Genome Data Viewer
Location:
3q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127057220..127092779)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106603273..106633428)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111422267..111452600)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5 Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene inositol-trisphosphate 3-kinase A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. Raemaekers T, et al. J Cell Biol, 2003 Sep 15. PMID 12963707, Free PMC Article
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of mitotic spindle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nucleolar and spindle-associated protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107762.2 → NP_001101232.1  nucleolar and spindle-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001101232.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HPG6, A6HPG7, D4AAK2
    Related
    ENSRNOP00000045376.3, ENSRNOT00000052312.5
    Conserved Domains (1) summary
    pfam16006
    Location:160 → 370
    NUSAP; Nucleolar and spindle-associated protein

  2. NM_001399531.1 → NP_001386460.1  nucleolar and spindle-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JXS3, B1WBZ5
    Related
    ENSRNOP00000070384.2, ENSRNOT00000081934.2
    Conserved Domains (1) summary
    pfam16006
    Location:160 → 410
    NUSAP; Nucleolar and spindle-associated protein

  3. NM_001399533.1 → NP_001386462.1  nucleolar and spindle-associated protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JXS3
    Conserved Domains (1) summary
    pfam16006
    Location:160 → 409
    NUSAP; Nucleolar and spindle-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    127057220..127092779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762101.3 → XP_008760323.1  nucleolar and spindle-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXS3
    Conserved Domains (1) summary
    pfam16006
    Location:154 → 380
    NUSAP; Nucleolar and spindle-associated protein

  2. XM_008762102.3 → XP_008760324.1  nucleolar and spindle-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JXS3, A0A8I6AB59
    Related
    ENSRNOP00000089210.1
    Conserved Domains (1) summary
    pfam16006
    Location:154 → 379
    NUSAP; Nucleolar and spindle-associated protein

  3. XM_006234770.4 → XP_006234832.1  nucleolar and spindle-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    A6HPG7
    Conserved Domains (1) summary
    pfam16006
    Location:111 → 361
    NUSAP; Nucleolar and spindle-associated protein

  4. XM_063283712.1 → XP_063139782.1  nucleolar and spindle-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    A6HPG7

  5. XM_063283713.1 → XP_063139783.1  nucleolar and spindle-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    A6HPG7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools