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Lrrc57 leucine rich repeat containing 57 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311346, updated on 17-Aug-2024

Summary

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Symbol
Lrrc57provided by RGD
Full Name
leucine rich repeat containing 57provided by RGD
Primary source
RGD:1307128
See related
EnsemblRapid:ENSRNOG00000009143 AllianceGenome:RGD:1307128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307128
Summary
Predicted to be located in membrane. Orthologous to human LRRC57 (leucine rich repeat containing 57). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 149.8), Kidney (RPKM 85.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrc57 in Genome Data Viewer
Location:
3q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127998535..128007004, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107544786..107553256, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112365936..112371787, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA15 Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene StAR-related lipid transfer domain containing 9 Neighboring gene uncharacterized LOC120101914 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109337

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 57
Names
leucine-rich repeat-containing protein 57-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012354.2 → NP_001012354.1  leucine-rich repeat-containing protein 57

    See identical proteins and their annotated locations for NP_001012354.1

    Status: VALIDATED

    Source sequence(s)
    BC089966, CV111644
    UniProtKB/Swiss-Prot
    Q5FVI3
    UniProtKB/TrEMBL
    A6HPK3, A6HPK4
    Conserved Domains (3) summary
    cd00116
    Location:23 → 191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:40 → 63
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:38 → 97
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    127998535..128007004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234777.5 → XP_006234839.1  leucine-rich repeat-containing protein 57 isoform X1

    UniProtKB/TrEMBL
    A6HPK3
    Conserved Domains (3) summary
    cd00116
    Location:48 → 216
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:65 → 88
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:63 → 122
    LRR_8; Leucine rich repeat

  2. XM_006234778.4 → XP_006234840.1  leucine-rich repeat-containing protein 57 isoform X2

    See identical proteins and their annotated locations for XP_006234840.1

    UniProtKB/Swiss-Prot
    Q5FVI3
    UniProtKB/TrEMBL
    A6HPK3, A6HPK4
    Conserved Domains (3) summary
    cd00116
    Location:23 → 191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:40 → 63
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:38 → 97
    LRR_8; Leucine rich repeat

  3. XM_006234780.5 → XP_006234842.1  leucine-rich repeat-containing protein 57 isoform X3

    UniProtKB/TrEMBL
    A6HPK3
    Related
    ENSRNOP00000050922.6, ENSRNOT00000049756.7
    Conserved Domains (3) summary
    cd00116
    Location:65 → 233
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:82 → 105
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:80 → 139
    LRR_8; Leucine rich repeat

  4. XM_006234779.5 → XP_006234841.1  leucine-rich repeat-containing protein 57 isoform X2

    See identical proteins and their annotated locations for XP_006234841.1

    UniProtKB/Swiss-Prot
    Q5FVI3
    UniProtKB/TrEMBL
    A6HPK3, A6HPK4
    Conserved Domains (3) summary
    cd00116
    Location:23 → 191
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:40 → 63
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:38 → 97
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVI3.1 GenPept UniProtKB/Swiss-Prot:Q5FVI3

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