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Ttbk2 tau tubulin kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311349, updated on 2-Nov-2024

Summary

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Official Symbol
Ttbk2provided by RGD
Official Full Name
tau tubulin kinase 2provided by RGD
Primary source
RGD:1311661
See related
EnsemblRapid:ENSRNOG00000011059 AllianceGenome:RGD:1311661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable kinesin binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including hindbrain development; negative regulation of microtubule depolymerization; and negative regulation of protein localization to microtubule. Predicted to act upstream of or within several processes, including embryonic brain development; nervous system development; and positive regulation of non-motile cilium assembly. Predicted to be located in centriole; ciliary base; and cytosol. Predicted to be active in several cellular components, including ciliary basal body; ciliary transition zone; and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 186.0), Testes (RPKM 94.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ttbk2 in Genome Data Viewer
Location:
3q35
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128144851..128256630, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107691123..107802911, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112677932..112789615, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene StAR-related lipid transfer domain containing 9 Neighboring gene uncharacterized LOC120101914 Neighboring gene codanin 1 Neighboring gene uncharacterized LOC134486141 Neighboring gene ubiquitin protein ligase E3 component n-recognin 1 Neighboring gene transmembrane protein 62

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau. Tomizawa K, et al. FEBS Lett, 2001 Mar 16. PMID 11257498
  2. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Bouskila M, et al. Biochem J, 2011 Jul 1. PMID 21548880, Free PMC Article
  3. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Goetz SC, et al. Cell, 2012 Nov 9. PMID 23141541, Free PMC Article
  4. TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. Watanabe T, et al. J Cell Biol, 2015 Aug 31. PMID 26323690, Free PMC Article
  5. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Ye X, et al. Proc Natl Acad Sci U S A, 2014 Feb 11. PMID 24469809, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellar granular layer development ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellar granule cell precursor tangential migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellum development ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tau-tubulin kinase 2
NP_001402630.1
XP_006234896.1
XP_006234897.1
XP_006234899.2
XP_038960877.1
XP_038960880.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415701.1 → NP_001402630.1  tau-tubulin kinase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JYZ1
    Related
    ENSRNOP00000108687.1, ENSRNOT00000128561.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128144851..128256630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234837.5 → XP_006234899.2  tau-tubulin kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AER0, A6HPL4, D3ZN60
    Related
    ENSRNOP00000090935.1, ENSRNOT00000107545.2
    Conserved Domains (1) summary
    cd14129
    Location:89 → 350
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2

  2. XM_039104949.2 → XP_038960877.1  tau-tubulin kinase 2 isoform X3

    UniProtKB/TrEMBL
    A6HPL4, D3ZN60
    Related
    ENSRNOP00000108922.1, ENSRNOT00000168510.1
    Conserved Domains (1) summary
    cl21453
    Location:4 → 212
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006234835.4 → XP_006234897.1  tau-tubulin kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006234897.1

    UniProtKB/TrEMBL
    A0A0G2JYZ1, A6HPL4, D3ZN60
    Conserved Domains (2) summary
    cd14129
    Location:20 → 281
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2
    pfam00069
    Location:21 → 260
    Pkinase; Protein kinase domain

  4. XM_006234834.5 → XP_006234896.1  tau-tubulin kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006234896.1

    UniProtKB/TrEMBL
    A0A0G2JYZ1, A6HPL4, D3ZN60
    Conserved Domains (2) summary
    cd14129
    Location:20 → 281
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2
    pfam00069
    Location:21 → 260
    Pkinase; Protein kinase domain

  5. XM_039104952.2 → XP_038960880.1  tau-tubulin kinase 2 isoform X4

    Conserved Domains (1) summary
    cd14129
    Location:89 → 350
    STKc_TTBK2; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107766.1: Suppressed sequence

    Description
    NM_001107766.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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