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Adal adenosine deaminase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 311352, updated on 2-Nov-2024

Summary

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Official Symbol
Adalprovided by RGD
Official Full Name
adenosine deaminase-likeprovided by RGD
Primary source
RGD:1359517
See related
EnsemblRapid:ENSRNOG00000012166 AllianceGenome:RGD:1359517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including deaminase activity; structural molecule activity; and zinc ion binding activity. Predicted to be involved in viral process. Orthologous to human ADAL (adenosine deaminase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 34.3), Thymus (RPKM 34.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adal in Genome Data Viewer
Location:
3q35
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128555604..128583809)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108101857..108119557)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113091696..113109841)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transglutaminase 5 Neighboring gene transglutaminase 7 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. Murakami E, et al. J Med Chem, 2011 Aug 25. PMID 21755941
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109297

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in viral process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenosine deaminase-like protein
NP_001014069.2
XP_008760388.1
XP_008760389.1
XP_008760391.1
XP_017447223.1
XP_017447225.1
XP_038960881.1
XP_038960882.1
XP_038960883.1
XP_063139784.1
XP_063139785.1
XP_063139786.1
XP_063139787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014047.2 → NP_001014069.2  adenosine deaminase-like protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    Related
    ENSRNOP00000111630.1, ENSRNOT00000159363.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128555604..128583809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762166.4 → XP_008760388.1  adenosine deaminase-like protein isoform X1

    Conserved Domains (1) summary
    cd00443
    Location:17 → 344
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  2. XM_017591734.3 → XP_017447223.1  adenosine deaminase-like protein isoform X1

    Conserved Domains (1) summary
    cd00443
    Location:17 → 344
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  3. XM_063283717.1 → XP_063139787.1  adenosine deaminase-like protein isoform X6

  4. XM_008762169.4 → XP_008760391.1  adenosine deaminase-like protein isoform X3

    Conserved Domains (1) summary
    cd00443
    Location:29 → 310
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  5. XM_039104955.2 → XP_038960883.1  adenosine deaminase-like protein isoform X3

    Conserved Domains (1) summary
    cd00443
    Location:29 → 310
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  6. XM_039104954.2 → XP_038960882.1  adenosine deaminase-like protein isoform X1

    Conserved Domains (1) summary
    cd00443
    Location:17 → 344
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  7. XM_063283714.1 → XP_063139784.1  adenosine deaminase-like protein isoform X1

  8. XM_039104953.2 → XP_038960881.1  adenosine deaminase-like protein isoform X1

    Conserved Domains (1) summary
    cd00443
    Location:17 → 344
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  9. XM_008762167.4 → XP_008760389.1  adenosine deaminase-like protein isoform X4

    UniProtKB/TrEMBL
    A0A8J8YAK5
    Conserved Domains (1) summary
    cd00443
    Location:1 → 230
    ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

  10. XM_017591736.3 → XP_017447225.1  adenosine deaminase-like protein isoform X5

    UniProtKB/TrEMBL
    A0A8J8YAK5, F1LRK5, Q5FVI8
    Conserved Domains (1) summary
    cl00281
    Location:3 → 201
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  11. XM_063283716.1 → XP_063139786.1  adenosine deaminase-like protein isoform X4

  12. XM_063283715.1 → XP_063139785.1  adenosine deaminase-like protein isoform X2

RNA

  1. XR_010064618.1 RNA Sequence

  2. XR_010064619.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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