Slc4a11 solute carrier family 4 member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc4a11provided by RGD
Official Full Name: solute carrier family 4 member 11provided by RGD
Primary source: RGD:1310188
See related: EnsemblRapid:ENSRNOG00000021234 AllianceGenome:RGD:1310188
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including active borate transmembrane transporter activity; monoatomic cation channel activity; and water transmembrane transporter activity. Predicted to be involved in several processes, including bicarbonate transport; cellular hypotonic response; and monoatomic cation transport. Located in basolateral plasma membrane and vesicle membrane. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 26.8), Thymus (RPKM 14.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138353305..138365983, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117900223..117912787, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123224242..123236535, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC4A11 is expressed relatively more abundantly in collecting ducts of the lower inner medulla where it is involved in ammonia recycling.
Title: Expression of SLC4A11 protein in mouse and rat medulla: a candidate transporter involved in outer medullary ammonia recycling.
We conclude that SLC4A11 is a rare integral membrane protein in which the CD has strong associations with the integral MD, which contributes to membrane transport function.
Title: The cytoplasmic domain is essential for transport function of the integral membrane transport protein SLC4A11.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139715 (e-PCR)
- UniSTS:221799

Slc4a11 (e-PCR), detects polymorphism
- UniSTS:546014

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables active borate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables proton channel activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in borate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in borate transport	ISO Inferred from Sequence Orthology more info
involved_in cellular hypotonic response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in fluid transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic cation homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 4 member 11

Names: sodium bicarbonate transporter-like protein 11; solute carrier family 4, sodium bicarbonate transporter-like, member 11; solute carrier family 4, sodium borate transporter, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.