Fitm2 fat storage-inducing transmembrane protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fitm2provided by RGD
Official Full Name: fat storage-inducing transmembrane protein 2provided by RGD
Primary source: RGD:1307696
See related: EnsemblRapid:ENSRNOG00000027434 AllianceGenome:RGD:1307696
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fit2; RGD1307696
Summary: Predicted to enable coenzyme A diphosphatase activity; diacylglycerol binding activity; and triglyceride binding activity. Predicted to be involved in several processes, including intracellular triglyceride homeostasis; lipid droplet formation; and positive regulation of sequestering of triglyceride. Predicted to act upstream of or within sequestering of triglyceride. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 466.7), Liver (RPKM 111.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (172560781..172567291, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152141346..152147858, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (159856994..159863506, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coenzyme A diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info
enables triglyceride binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular triglyceride homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sequestering of triglyceride	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sequestering of triglyceride	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acyl-coenzyme A diphosphatase FITM2

Names: fat-inducing transcript 2

NP_001101269.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.