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Actn - alpha actinin

Enables actin filament binding activity. Involved in actin filament bundle assembly and sarcomere organization. Located in Z disc. Is expressed in several structures, including adult head; adult heart; ganglia; mesoderm; and muscle cell. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in congenital myopathy 8; focal segmental glomerulosclerosis (multiple); intrinsic cardiomyopathy (multiple); and platelet-type bleeding disorder 15. Orthologous to several human genes including ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Oct 2024]

Genes similar to Actn

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Species Gene Architecture aa