Slc27a4 solute carrier family 27 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc27a4provided by RGD
Official Full Name: solute carrier family 27 member 4provided by RGD
Primary source: RGD:1307383
See related: EnsemblRapid:ENSRNOG00000014369 AllianceGenome:RGD:1307383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fatp4
Summary: Predicted to enable fatty acid-CoA ligase activity and long-chain fatty acid transmembrane transporter activity. Involved in response to nutrient. Predicted to be located in brush border membrane; endoplasmic reticulum; and microvillus. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Biomarker of steatotic liver disease. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 110.0), Adrenal (RPKM 76.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33472903..33485824)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13075022..13087943)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8363937..8376858)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vitamin D and Swimming Exercise Prevent Obesity in Rats under a High-Fat Diet via Targeting FATP4 and TLR4 in the Liver and Adipose Tissue.
Title: Vitamin D and Swimming Exercise Prevent Obesity in Rats under a High-Fat Diet via Targeting FATP4 and TLR4 in the Liver and Adipose Tissue.
FAT/CD36 and FATP4 are the most effective fatty acid transporters in skeletal muscle.
Title: Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle.
Refeeding after both fasting phases induces an increase in FATP4 accompanied by a rapid lipid uptake by the enterocytes at the tip of the villi and a rapid extension of the lamina propria due to inflated lymphatic vessels.
Title: Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132571 (e-PCR)
- UniSTS:215854

BF417583 (e-PCR)
- UniSTS:249686

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oleoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within medium-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within very long-chain fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: long-chain fatty acid transport protein 4

Names: fatty acid transport protein 4; solute carrier family 27 (fatty acid transporter), member 4

NP_001094176.1

EC 6.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100706.1 → NP_001094176.1 long-chain fatty acid transport protein 4

See identical proteins and their annotated locations for NP_001094176.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTS4, G3V7V3

Related

ENSRNOP00000019500.4, ENSRNOT00000019500.8

Conserved Domains (2) summary

cd05939
Location:99 → 608

hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

PRK08279
Location:75 → 643

PRK08279; long-chain-acyl-CoA synthetase; Validated