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Kyat1 kynurenine aminotransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311844, updated on 17-Aug-2024

Summary

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Official Symbol
Kyat1provided by RGD
Official Full Name
kynurenine aminotransferase 1provided by RGD
Primary source
RGD:1306912
See related
EnsemblRapid:ENSRNOG00000016097 AllianceGenome:RGD:1306912
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gtk; Kat1; KatI; Ccbl1
Summary
Enables cysteine-S-conjugate beta-lyase activity and glutamine-phenylpyruvate transaminase activity. Involved in L-kynurenine metabolic process and pyruvate metabolic process. Located in cytosol and mitochondrion. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 733.3), Liver (RPKM 132.6) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33857407..33891153, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13459598..13493308, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8752289..8785617, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 13 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC120101891 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs. Mosca M, et al. Biochim Biophys Acta, 2003 Jul 9. PMID 12850267
  2. Cloning and expression of a rat kidney cytosolic glutamine transaminase K that has strong sequence homology to kynurenine pyruvate aminotransferase. Abraham DG, et al. Arch Biochem Biophys, 1996 Nov 15. PMID 8914928
  3. Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase. Perry SJ, et al. Mol Pharmacol, 1993 May. PMID 8502223
  4. Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K. Mosca M, et al. FEBS Lett, 1994 Oct 10. PMID 7926014
  5. Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains. Abraham DG, et al. Anal Biochem, 1991 Sep 2. PMID 1723851

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. neuronal culture showed positive immunostaining for both kynurenic acid aminotransferase (KAT) isoforms I and II
    Title: Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons.
  2. identification of presence in the permanent immature rat oligodendrocyte cell line OLN-93
    Title: Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).
  3. study demonstrated that several KATI mRNAs are constitutively expressed in ubiquitous manner; Each KATI mRNA exhibits a different in vitro translational efficiency, which corresponds to different levels of KAT enzymatic activity in transfected cells
    Title: Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-S-conjugate beta-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-S-conjugate beta-lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamine-phenylpyruvate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine-oxoglutarate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-kynurenine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-kynurenine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kynurenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in kynurenine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pyruvate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kynurenine--oxoglutarate transaminase 1
Names
cysteine conjugate-beta lyase 1
cysteine conjugate-beta lyase, cytoplasmic
cysteine-S-conjugate beta-lyase
glutamine transaminase K
glutamine--phenylpyruvate transaminase
kynurenine aminotransferase I
kynurenine aminotransferase/glutamine transaminase K
kynurenine--oxoglutarate transaminase 1, mitochondrial
kynurenine--oxoglutarate transaminase I
NP_001013182.3
XP_006233873.1
XP_008759880.1
XP_008759881.1
XP_038961158.1
XP_038961159.1
XP_038961160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013164.3 → NP_001013182.3  kynurenine--oxoglutarate transaminase 1

    See identical proteins and their annotated locations for NP_001013182.3

    Status: PROVISIONAL

    Source sequence(s)
    AF100154
    UniProtKB/Swiss-Prot
    Q08415, Q9R096
    Related
    ENSRNOP00000021865.4, ENSRNOT00000021865.8
    Conserved Domains (2) summary
    cd00609
    Location:65 → 451
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:58 → 454
    PRK08912; hypothetical protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33857407..33891153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761658.3 → XP_008759880.1  kynurenine--oxoglutarate transaminase 1 isoform X1

    See identical proteins and their annotated locations for XP_008759880.1

    UniProtKB/Swiss-Prot
    Q08415, Q9R096
    UniProtKB/TrEMBL
    A6JTW0
    Conserved Domains (1) summary
    PRK08912
    Location:58 → 454
    PRK08912; aminotransferase

  2. XM_008761659.4 → XP_008759881.1  kynurenine--oxoglutarate transaminase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q08415, Q9R096
    UniProtKB/TrEMBL
    A0A8I5ZZT5
    Related
    ENSRNOP00000085700.1, ENSRNOT00000102626.2
    Conserved Domains (1) summary
    cd00609
    Location:65 → 384
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

  3. XM_039105232.2 → XP_038961160.1  kynurenine--oxoglutarate transaminase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZSP9
    Conserved Domains (1) summary
    PRK08912
    Location:2 → 333
    PRK08912; aminotransferase

  4. XM_006233811.4 → XP_006233873.1  kynurenine--oxoglutarate transaminase 1 isoform X3

    See identical proteins and their annotated locations for XP_006233873.1

    UniProtKB/Swiss-Prot
    Q08415, Q9R096
    Conserved Domains (2) summary
    cd00609
    Location:31 → 417
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PRK08912
    Location:24 → 420
    PRK08912; hypothetical protein; Provisional

  5. XM_039105231.2 → XP_038961159.1  kynurenine--oxoglutarate transaminase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q08415, Q9R096
    UniProtKB/TrEMBL
    A0A8I6AEE2
    Related
    ENSRNOP00000091831.1, ENSRNOT00000095192.2
    Conserved Domains (1) summary
    PRK08912
    Location:50 → 446
    PRK08912; aminotransferase

  6. XM_039105230.2 → XP_038961158.1  kynurenine--oxoglutarate transaminase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08415, Q9R096
    UniProtKB/TrEMBL
    A6JTW0
    Related
    ENSRNOP00000108587.1, ENSRNOT00000159811.1
    Conserved Domains (1) summary
    PRK08912
    Location:58 → 454
    PRK08912; aminotransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08415.2 GenPept UniProtKB/Swiss-Prot:Q08415

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