Dolk dolichol kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dolkprovided by RGD
Official Full Name: dolichol kinaseprovided by RGD
Primary source: RGD:1310821
See related: EnsemblRapid:ENSRNOG00000016989 AllianceGenome:RGD:1310821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem15
Summary: Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process and protein mannosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33955642..33957680, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13557826..13559864, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8850154..8852192, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dolichol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichol kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dolichyl monophosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichyl monophosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein mannosylation	IEA Inferred from Electronic Annotation more info
involved_in protein mannosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dolichol kinase

Names: transmembrane protein 15

NP_001101296.1

EC 2.7.1.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.