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Dolk dolichol kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 311847, updated on 14-Nov-2024

Summary

Official Symbol
Dolkprovided by RGD
Official Full Name
dolichol kinaseprovided by RGD
Primary source
RGD:1310821
See related
EnsemblRapid:ENSRNOG00000016989 AllianceGenome:RGD:1310821
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem15
Summary
Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process and protein mannosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Dolk in Genome Data Viewer
Location:
3p12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33955642..33957680, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13557826..13559864, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8850154..8852192, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC120101891 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene nucleoporin 188 Neighboring gene SH3 domain-containing GRB2-like endophilin B2

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dolichol kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dolichol phosphate mannose biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dolichyl monophosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dolichyl monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein mannosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dolichol kinase
Names
transmembrane protein 15
NP_001101296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107826.1NP_001101296.1  dolichol kinase

    See identical proteins and their annotated locations for NP_001101296.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/TrEMBL
    A6JTW9, D3ZLM6
    Related
    ENSRNOP00000022786.1, ENSRNOT00000022786.5
    Conserved Domains (1) summary
    cl21502
    Location:333522
    CTP_transf_1; Cytidylyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33955642..33957680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)