Tor1b torsin family 1, member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tor1bprovided by RGD
Official Full Name: torsin family 1, member Bprovided by RGD
Primary source: RGD:1308431
See related: EnsemblRapid:ENSRNOG00000006435 AllianceGenome:RGD:1308431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP hydrolysis activity; identical protein binding activity; and kinesin binding activity. Predicted to be involved in endoplasmic reticulum organization; nuclear membrane organization; and protein localization to nucleus. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen and nuclear envelope. Orthologous to human TOR1B (torsin family 1 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 101.0), Kidney (RPKM 94.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34640929..34647023)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (14243181..14249279)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (9792818..9798924)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF403122 (e-PCR)
- UniSTS:246315

RH132332 (e-PCR)
- UniSTS:215615

BE097431 (e-PCR)
- UniSTS:244663

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear membrane organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear membrane organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: torsin-1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039197.1 → NP_001034286.1 torsin-1B precursor

See identical proteins and their annotated locations for NP_001034286.1

Status: PROVISIONAL

Source sequence(s)

BC111704

UniProtKB/TrEMBL

A6JU10, F7ES66, Q2M2S1

Related

ENSRNOP00000062610.1, ENSRNOT00000066618.5

Conserved Domains (2) summary

COG0542
Location:60 → 292

ClpA; ATP-dependent Clp protease ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones]

pfam06309
Location:62 → 176

Torsin