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Mrrf mitochondrial ribosome recycling factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 311903, updated on 10-Jul-2024

Summary

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Official Symbol
Mrrfprovided by RGD
Official Full Name
mitochondrial ribosome recycling factorprovided by RGD
Primary source
RGD:1305897
See related
EnsemblRapid:ENSRNOG00000025997 AllianceGenome:RGD:1305897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosome disassembly and translation. Predicted to be active in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 93.7), Adrenal (RPKM 68.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrrf in Genome Data Viewer
Location:
3p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (39884530..39941317)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (19487124..19543911)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (15463884..15520621)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene MORN repeat containing 5 Neighboring gene uncharacterized LOC134486080 Neighboring gene LIM homeobox 6 Neighboring gene RNA binding motif protein 18 Neighboring gene uncharacterized LOC120101536 Neighboring gene prostaglandin-endoperoxide synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Tsuboi M, et al. Mol Cell, 2009 Aug 28. PMID 19716793
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93722

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribosome-recycling factor, mitochondrial
Names
RRF
ribosome-releasing factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008354.1 → NP_001008355.1  ribosome-recycling factor, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001008355.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085779
    UniProtKB/Swiss-Prot
    Q5RKI9
    Related
    ENSRNOP00000038041.3, ENSRNOT00000033047.5
    Conserved Domains (1) summary
    pfam01765
    Location:99 → 260
    RRF; Ribosome recycling factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    39884530..39941317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105267.1 → XP_038961195.1  ribosome-recycling factor, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I6G9D1
    Related
    ENSRNOP00000083698.1, ENSRNOT00000113456.2
    Conserved Domains (1) summary
    pfam01765
    Location:99 → 184
    RRF; Ribosome recycling factor

  2. XM_006234069.3 → XP_006234131.1  ribosome-recycling factor, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam01765
    Location:64 → 208
    RRF; Ribosome recycling factor

  3. XM_063283974.1 → XP_063140044.1  ribosome-recycling factor, mitochondrial isoform X4

  4. XM_063283975.1 → XP_063140045.1  ribosome-recycling factor, mitochondrial isoform X6

  5. XM_039105266.2 → XP_038961194.1  ribosome-recycling factor, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q5RKI9
    Conserved Domains (1) summary
    pfam01765
    Location:99 → 260
    RRF; Ribosome recycling factor

  6. XM_063283973.1 → XP_063140043.1  ribosome-recycling factor, mitochondrial isoform X3

  7. XM_039105268.1 → XP_038961196.1  ribosome-recycling factor, mitochondrial isoform X5

    Conserved Domains (1) summary
    pfam01765
    Location:8 → 169
    RRF; Ribosome recycling factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RKI9.1 GenPept UniProtKB/Swiss-Prot:Q5RKI9

Gene LinkOut

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