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Steap2 STEAP2 metalloreductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 312052, updated on 17-Aug-2024

Summary

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Official Symbol
Steap2provided by RGD
Official Full Name
STEAP2 metalloreductaseprovided by RGD
Primary source
RGD:1307050
See related
EnsemblRapid:ENSRNOG00000006076 AllianceGenome:RGD:1307050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cupric reductase activity and ferric-chelate reductase (NADPH) activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; copper ion import; and regulated exocytosis. Predicted to act upstream of or within copper ion import across plasma membrane and iron ion import across plasma membrane. Predicted to be located in cytosol; early endosome; and trans-Golgi network transport vesicle. Predicted to be integral component of Golgi membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 206.7), Brain (RPKM 50.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29302487..29323006)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28347769..28368177)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25506604..25527088)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene high mobility group box 3 like 2 Neighboring gene STEAP family member 1 Neighboring gene uncharacterized LOC134486556 Neighboring gene cilia and flagella associated protein 69 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. Tokuda E, et al. J Neurochem, 2009 Oct. PMID 19656261
  2. Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. Korkmaz KS, et al. J Biol Chem, 2002 Sep 27. PMID 12095985
  3. The Steap proteins are metalloreductases. Ohgami RS, et al. Blood, 2006 Aug 15. PMID 16609065, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cupric reductase (NADH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cupric reductase (NADH) activity ISO
Inferred from Sequence Orthology
more info
  
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric-chelate reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within copper ion import ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within copper ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within iron ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metalloreductase STEAP2
Names
STEAP family member 2, metalloreductase
six transmembrane epithelial antigen of prostate 2
six transmembrane epithelial antigen of the prostate 2
NP_001101316.1
XP_006236094.1
XP_006236096.1
XP_006236098.1
XP_008760925.1
XP_038963433.1
XP_063142035.1
XP_063142036.1
XP_063142037.1
XP_063142039.1
XP_063142040.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107846.1 → NP_001101316.1  metalloreductase STEAP2

    See identical proteins and their annotated locations for NP_001101316.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474013
    UniProtKB/TrEMBL
    A0A8I6ABY6, A6K253, A6K255, D4A6H3
    Related
    ENSRNOP00000007977.5, ENSRNOT00000007977.7
    Conserved Domains (3) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:33 → 118
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    29302487..29323006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236032.5 → XP_006236094.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_006236094.1

    UniProtKB/TrEMBL
    A0A8I6ABY6, A6K253, A6K255, D4A6H3
    Conserved Domains (3) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:33 → 118
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  2. XM_006236036.5 → XP_006236098.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_006236098.1

    UniProtKB/TrEMBL
    A0A8I6ABY6, A6K253, A6K255, D4A6H3
    Conserved Domains (3) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:33 → 118
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  3. XM_063285970.1 → XP_063142040.1  metalloreductase STEAP2 isoform X2

  4. XM_063285966.1 → XP_063142036.1  metalloreductase STEAP2 isoform X2

  5. XM_006236034.5 → XP_006236096.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_006236096.1

    UniProtKB/TrEMBL
    A0A8I6ABY6, A6K253, A6K255, D4A6H3
    Conserved Domains (3) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:33 → 118
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  6. XM_039107505.2 → XP_038963433.1  metalloreductase STEAP2 isoform X2

    Conserved Domains (1) summary
    COG2085
    Location:31 → 219
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

  7. XM_008762703.4 → XP_008760925.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_008760925.1

    UniProtKB/TrEMBL
    A0A8I6ABY6, A6K253, A6K255, D4A6H3
    Conserved Domains (3) summary
    COG2085
    Location:31 → 216
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:261 → 404
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:33 → 118
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  8. XM_063285965.1 → XP_063142035.1  metalloreductase STEAP2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABY6, A6K253, A6K255, D4A6H3

  9. XM_063285969.1 → XP_063142039.1  metalloreductase STEAP2 isoform X2

  10. XM_063285967.1 → XP_063142037.1  metalloreductase STEAP2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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