Vsig4 V-set and immunoglobulin domain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vsig4provided by RGD
Official Full Name: V-set and immunoglobulin domain containing 4provided by RGD
Primary source: RGD:1564659
See related: EnsemblRapid:ENSRNOG00000038132 AllianceGenome:RGD:1564659
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable complement component C3b binding activity. Involved in positive regulation of gene expression. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Orthologous to human VSIG4 (V-set and immunoglobulin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 189.4), Spleen (RPKM 17.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (65154422..65179708, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (61144926..61170212, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (65370851..65400298, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement component C3b binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C3b binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement activation, alternative pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: V-set and immunoglobulin domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.