Tmem106b transmembrane protein 106B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem106bprovided by RGD
Official Full Name: transmembrane protein 106Bprovided by RGD
Primary source: RGD:1303037
See related: EnsemblRapid:ENSRNOG00000006206 AllianceGenome:RGD:1303037
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRGT00101
Summary: Predicted to enable ATPase binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; lysosome localization; and lysosome organization. Predicted to act upstream of or within several processes, including lysosomal lumen acidification; lysosomal protein catabolic process; and positive regulation of dendrite development. Predicted to be located in endosome and lysosome. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 16. Orthologous to human TMEM106B (transmembrane protein 106B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 447.2), Kidney (RPKM 359.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (42294074..42313426)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (41328125..41347315)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (39517679..39534491)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lysosomal lumen acidification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lysosome organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 106B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004267.1 → NP_001004267.1 transmembrane protein 106B

See identical proteins and their annotated locations for NP_001004267.1

Status: PROVISIONAL

Source sequence(s)

BC079127

UniProtKB/Swiss-Prot

Q6AYA5

UniProtKB/TrEMBL

A0A8I6AL12, A6IDZ5

Conserved Domains (1) summary

pfam07092
Location:34 → 259

DUF1356; Protein of unknown function (DUF1356)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

42294074..42313426

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107507.2 → XP_038963435.1 transmembrane protein 106B isoform X1

UniProtKB/Swiss-Prot

Q6AYA5

UniProtKB/TrEMBL

A0A8I6AL12, A6IDZ5

Related

ENSRNOP00000008677.3, ENSRNOT00000008677.6

Conserved Domains (1) summary

pfam07092
Location:34 → 259

DUF1356; Protein of unknown function (DUF1356)