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Ing3 inhibitor of growth family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312154, updated on 2-Nov-2024

Summary

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Official Symbol
Ing3provided by RGD
Official Full Name
inhibitor of growth family, member 3provided by RGD
Primary source
RGD:1310556
See related
EnsemblRapid:ENSRNOG00000005496 AllianceGenome:RGD:1310556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone H4 acetyltransferase activity and methylated histone binding activity. Predicted to contribute to histone H2A acetyltransferase activity and histone H4 acetyltransferase activity. Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of DNA-templated transcription; and regulation of cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of chromatin and piccolo histone acetyltransferase complex. Used to study hepatocellular carcinoma. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 52.1), Spleen (RPKM 41.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ing3 in Genome Data Viewer
Location:
4q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (51439218..51469502)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (50477954..50505168)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (49017235..49044450)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 12 Neighboring gene cytochrome c oxidase subunit 6C-2-like Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene Wnt family member 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular mechanisms of nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats. Ahmed HH, et al. Toxicol Mech Methods, 2014 Dec. PMID 25156538
  2. Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling. Wang J, et al. Arch Biochem Biophys, 2014 Nov 15. PMID 25151306
  3. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. Lee WY, et al. Plant J, 2009 May. PMID 19154204
  4. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974, Free PMC Article
  5. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Obri A, et al. Nature, 2014 Jan 30. PMID 24463511

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ING3 bas a role in inducing cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling
    Title: Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC112729

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to histone H2A acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K16 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Swr1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of piccolo histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of piccolo histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034107.2 → NP_001029279.1  inhibitor of growth protein 3

    See identical proteins and their annotated locations for NP_001029279.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q498T3
    UniProtKB/TrEMBL
    A0A8I6A977
    Related
    ENSRNOP00000088161.2, ENSRNOT00000104929.2
    Conserved Domains (3) summary
    COG5034
    Location:4 → 413
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:365 → 409
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 102
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    51439218..51469502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236140.4 → XP_006236202.1  inhibitor of growth protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A977
    Conserved Domains (3) summary
    COG5034
    Location:4 → 402
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15585
    Location:354 → 398
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    pfam12998
    Location:3 → 102
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. XM_006236141.4 → XP_006236203.1  inhibitor of growth protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006236203.1

    UniProtKB/TrEMBL
    A0A8I6A977, A6IE55
    Related
    ENSRNOP00000007476.5, ENSRNOT00000007476.7
    Conserved Domains (2) summary
    cd15585
    Location:341 → 385
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    cd16858
    Location:8 → 74
    ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins

  3. XM_063285972.1 → XP_063142042.1  inhibitor of growth protein 3 isoform X3

  4. XM_039107508.2 → XP_038963436.1  inhibitor of growth protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A977
    Conserved Domains (2) summary
    cd15585
    Location:330 → 374
    PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
    cd16858
    Location:1 → 63
    ING_ING3_Yng2p; Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q498T3.1 GenPept UniProtKB/Swiss-Prot:Q498T3

Gene LinkOut

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