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Cadps2 calcium dependent secretion activator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312166, updated on 2-Nov-2024

Summary

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Official Symbol
Cadps2provided by RGD
Official Full Name
calcium dependent secretion activator 2provided by RGD
Primary source
RGD:1559440
See related
EnsemblRapid:ENSRNOG00000007636 AllianceGenome:RGD:1559440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559440
Summary
Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to act upstream of or within cellular response to starvation; hematopoietic stem cell homeostasis; and synaptic vesicle priming. Predicted to be located in cytoplasmic vesicle; nucleoplasm; and synaptic membrane. Predicted to be active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynapse. Orthologous to human CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 327.6), Lung (RPKM 69.6) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cadps2 in Genome Data Viewer
Location:
4q22
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (52746054..53275252, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (51780415..52309641, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (50326447..50861161, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486670 Neighboring gene uncharacterized LOC134486742 Neighboring gene Fez family zinc finger 1 Neighboring gene uncharacterized LOC134486740 Neighboring gene ring finger protein 133 Neighboring gene ring finger protein 148 Neighboring gene uncharacterized LOC108350675 Neighboring gene taste receptor, type 2, member 118 Neighboring gene solute carrier family 13 member 1 Neighboring gene thyroid hormone receptor associated protein 3, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain. Nguyen Truong CQ, et al. Cell Rep, 2014 Nov 6. PMID 25437547
  2. Survival adjustment of mature dendritic cells by IL-15. Dubois SP, et al. Proc Natl Acad Sci U S A, 2005 Jun 14. PMID 15932944, Free PMC Article
  3. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. Sadakata T, et al. J Neurosci, 2004 Jan 7. PMID 14715936, Free PMC Article
  4. The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Imig C, et al. Neuron, 2014 Oct 22. PMID 25374362
  5. SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Burgalossi A, et al. Neuron, 2010 Nov 4. PMID 21040848

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-dependent secretion activator 2
Names
Ca++-dependent secretion activator 2
Ca2+ dependent secretion activator 2
Ca2+-dependent activator protein for secretion 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427791.1 → NP_001414720.1  calcium-dependent secretion activator 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000085438.2, ENSRNOT00000117045.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    52746054..53275252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285976.1 → XP_063142046.1  calcium-dependent secretion activator 2 isoform X4

  2. XM_039108614.2 → XP_038964542.1  calcium-dependent secretion activator 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZKA3
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 892
    DUF1041; Domain of Unknown Function (DUF1041)

  3. XM_002729291.6 → XP_002729337.1  calcium-dependent secretion activator 2 isoform X7

    See identical proteins and their annotated locations for XP_002729337.1

    UniProtKB/TrEMBL
    A0A8I5ZKA3
    Related
    ENSRNOP00000080739.2, ENSRNOT00000119022.2
    Conserved Domains (4) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 592
    PH; PH domain
    pfam06292
    Location:802 → 892
    DUF1041; Domain of Unknown Function (DUF1041)

  4. XM_063285979.1 → XP_063142049.1  calcium-dependent secretion activator 2 isoform X10

  5. XM_063285975.1 → XP_063142045.1  calcium-dependent secretion activator 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AHC2
    Related
    ENSRNOP00000077855.2, ENSRNOT00000119282.2

  6. XM_063285977.1 → XP_063142047.1  calcium-dependent secretion activator 2 isoform X5

  7. XM_063285973.1 → XP_063142043.1  calcium-dependent secretion activator 2 isoform X1

  8. XM_039108612.2 → XP_038964540.1  calcium-dependent secretion activator 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZKA3
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 899
    DUF1041; Domain of Unknown Function (DUF1041)

  9. XM_063285974.1 → XP_063142044.1  calcium-dependent secretion activator 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GDI0, A6IE75
    Related
    ENSRNOP00000097144.2, ENSRNOT00000108432.2

  10. XM_063285978.1 → XP_063142048.1  calcium-dependent secretion activator 2 isoform X9

Nucleotide Protein Strain
Heading Accession and Version

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