U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nrf1 nuclear respiratory factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312195, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Nrf1provided by RGD
Official Full Name
nuclear respiratory factor 1provided by RGD
Primary source
RGD:1304603
See related
EnsemblRapid:ENSRNOG00000008752 AllianceGenome:RGD:1304603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nfe2l1_retired
Summary
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Confusion has occurred in bibliographic databases for genes in the "nuclear respiratory factor" and "nuclear factor (erythroid-derived 2)-like" families due to a shared symbol or alias of Nrf1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in Thymus (RPKM 147.5), Spleen (RPKM 95.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nrf1 in Genome Data Viewer
Location:
4q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59632366..59738166)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58664932..58772328)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57335732..57445317)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small lysine-rich protein 1 Neighboring gene uncharacterized LOC120102484 Neighboring gene microRNA 182 Neighboring gene microRNA 96

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway. Li H, et al. Cell Biol Int, 2021 Aug. PMID 33913583
  2. Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function. Li Y, et al. Cardiovasc Toxicol, 2021 Jun. PMID 33582931
  3. Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling. Wang X, et al. J Mol Cell Biol, 2021 May 7. PMID 33475136, Free PMC Article
  4. Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells. Niu N, et al. Mol Med Rep, 2019 Mar. PMID 30628711, Free PMC Article
  5. Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis. Hsieh PF, et al. Exp Cell Res, 2016 Nov 15. PMID 27634749

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of 12-wk Training in Ovariectomised Rats on PGC-1alpha, NRF-1 and Energy Substrates.
    Title: Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates.
  2. Effects of NRF-1 and PGC-1alpha cooperation on HIF-1alpha and rat cardiomyocyte apoptosis under hypoxia.
    Title: Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia.
  3. Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
    Title: Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
  4. Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-kappaB signaling.
    Title: Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling.
  5. Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
    Title: Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
  6. NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.
    Title: NRF1-enhanced miR-4458 alleviates cardiac hypertrophy through releasing TTP-inhibited TFAM.
  7. Identification of microRNA3633p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53signaling pathway.
    Title: Identification of microRNA‑363‑3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53‑signaling pathway.
  8. NRF1 regulates testosterone synthesis through transcription regulation of Star.
    Title: Transcription regulation of NRF1 on StAR reduces testosterone synthesis in hypoxemic murine.
  9. the present study demonstrated that NRF1 protected against CoCl2induced apoptosis, potentially by strengthening mitochondrial function to resist CoCl2induced damage to H9C2 cells. The results of the present study provide a possible way for the investigation of myocardial diseases.
    Title: Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells.
  10. Our findings suggest that NRF-1 regulates the expression of CXCR4 in normal retinal development and in pathologic processes of retinal hypoxia and neovascularization.
    Title: Nuclear Respiratory Factor-1 (NRF-1) Regulates Transcription of the CXC Receptor 4 (CXCR4) in the Rat Retina.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in response to electrical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to folic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear respiratory factor 1
Names
NRF-1
alpha palindromic-binding protein
alpha-pal

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100708.1 → NP_001094178.1  nuclear respiratory factor 1

    See identical proteins and their annotated locations for NP_001094178.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161956
    UniProtKB/TrEMBL
    A6IEF3, B1WC04, F7FCI9
    Related
    ENSRNOP00000094397.1, ENSRNOT00000117472.2
    Conserved Domains (2) summary
    cd04867
    Location:450 → 525
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    59632366..59738166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107511.2 → XP_038963439.1  nuclear respiratory factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2KA43
    Related
    ENSRNOP00000075252.2, ENSRNOT00000080173.3
    Conserved Domains (2) summary
    pfam10492
    Location:462 → 505
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  2. XM_006236200.5 → XP_006236262.1  nuclear respiratory factor 1 isoform X8

    Related
    ENSRNOP00000079043.1, ENSRNOT00000104816.2
    Conserved Domains (2) summary
    pfam10492
    Location:470 → 523
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  3. XM_006236198.5 → XP_006236260.1  nuclear respiratory factor 1 isoform X4

    See identical proteins and their annotated locations for XP_006236260.1

    UniProtKB/TrEMBL
    A0A8I6ALN8, A6IEF2
    Related
    ENSRNOP00000091041.2, ENSRNOT00000118984.2
    Conserved Domains (2) summary
    pfam10492
    Location:450 → 493
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  4. XM_063285983.1 → XP_063142053.1  nuclear respiratory factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2KA43

  5. XM_063285984.1 → XP_063142054.1  nuclear respiratory factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ALN8, A6IEF2

  6. XM_017592611.3 → XP_017448100.1  nuclear respiratory factor 1 isoform X1

    Related
    ENSRNOP00000011851.3, ENSRNOT00000011851.5
    Conserved Domains (2) summary
    cd04867
    Location:462 → 537
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  7. XM_017592612.3 → XP_017448101.1  nuclear respiratory factor 1 isoform X1

    Conserved Domains (2) summary
    cd04867
    Location:462 → 537
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  8. XM_063285982.1 → XP_063142052.1  nuclear respiratory factor 1 isoform X2

    UniProtKB/TrEMBL
    A6IEF3, B1WC04, F7FCI9

  9. XM_039107513.2 → XP_038963441.1  nuclear respiratory factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ALN8
    Conserved Domains (1) summary
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  10. XM_039107512.2 → XP_038963440.1  nuclear respiratory factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ALN8
    Conserved Domains (1) summary
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  11. XM_039107514.2 → XP_038963442.1  nuclear respiratory factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZWF5, A0A8I6ALN8
    Related
    ENSRNOP00000083755.1, ENSRNOT00000115640.2
    Conserved Domains (1) summary
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  12. XM_063285985.1 → XP_063142055.1  nuclear respiratory factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZWF5, A0A8I6ALN8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62792.1 GenPept UniProtKB/Swiss-Prot:Q62792

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools