U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kbtbd2 kelch repeat and BTB domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312372, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Kbtbd2provided by RGD
Official Full Name
kelch repeat and BTB domain containing 2provided by RGD
Primary source
RGD:1310317
See related
EnsemblRapid:ENSRNOG00000013809 AllianceGenome:RGD:1310317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of cellular response to insulin stimulus. Predicted to act upstream of or within with a positive effect on several processes, including glucose metabolic process; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to insulin. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD2 (kelch repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 136.4), Lung (RPKM 130.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Kbtbd2 in Genome Data Viewer
Location:
4q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (87358133..87380399, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (86027947..86050266, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (87088759..87111576, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene AVL9 cell migration associated Neighboring gene FKBP prolyl isomerase 9 Neighboring gene 5'-nucleotidase, cytosolic IIIA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2016 Oct 18. PMID 27708159, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_positive_effect glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_positive_effect lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_positive_effect phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_positive_effect response to insulin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kelch repeat and BTB domain-containing protein 2
Names
kelch repeat and BTB (POZ) domain containing 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107861.1 → NP_001101331.1  kelch repeat and BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_001101331.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474011
    UniProtKB/TrEMBL
    A6K117, D3ZVS6
    Related
    ENSRNOP00000018442.5, ENSRNOT00000018442.7
    Conserved Domains (4) summary
    PHA03098
    Location:23 → 516
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:374 → 415
    Kelch; KELCH repeat [structural motif]
    cd18270
    Location:5 → 137
    BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
    cd18479
    Location:128 → 223
    BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    87358133..87380399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762892.4 → XP_008761114.1  kelch repeat and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008761114.1

    UniProtKB/TrEMBL
    A6K117, D3ZVS6
    Conserved Domains (4) summary
    PHA03098
    Location:23 → 516
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:374 → 415
    Kelch; KELCH repeat [structural motif]
    cd18270
    Location:5 → 137
    BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
    cd18479
    Location:128 → 223
    BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

  2. XM_006236548.5 → XP_006236610.1  kelch repeat and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006236610.1

    UniProtKB/TrEMBL
    A6K117, D3ZVS6
    Conserved Domains (4) summary
    PHA03098
    Location:23 → 516
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:374 → 415
    Kelch; KELCH repeat [structural motif]
    cd18270
    Location:5 → 137
    BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
    cd18479
    Location:128 → 223
    BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

  3. XM_008762893.4 → XP_008761115.1  kelch repeat and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008761115.1

    UniProtKB/TrEMBL
    A6K117, D3ZVS6
    Conserved Domains (4) summary
    PHA03098
    Location:23 → 516
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:374 → 415
    Kelch; KELCH repeat [structural motif]
    cd18270
    Location:5 → 137
    BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
    cd18479
    Location:128 → 223
    BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

  4. XM_063286038.1 → XP_063142108.1  kelch repeat and BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6K117, D3ZVS6

  5. XM_063286037.1 → XP_063142107.1  kelch repeat and BTB domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6K117, D3ZVS6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools