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Immt inner membrane mitochondrial protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 312444, updated on 17-Aug-2024

Summary

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Official Symbol
Immtprovided by RGD
Official Full Name
inner membrane mitochondrial proteinprovided by RGD
Primary source
RGD:1310684
See related
EnsemblRapid:ENSRNOG00000009097 AllianceGenome:RGD:1310684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in response to cold. Located in mitochondrion. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1158.9), Kidney (RPKM 790.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105438657..105477370)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103880482..103919116)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99753446..99789921)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486590 Neighboring gene receptor accessory protein 1 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene Pentatricopeptide repeat domain 3 Neighboring gene RNA polymerase I subunit A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage. Deng R, et al. Mol Neurobiol, 2021 Oct. PMID 34232477
  2. Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone. Van Laar VS, et al. Neurobiol Dis, 2016 Jul. PMID 27001148, Free PMC Article
  3. Spatially distinct mitochondrial populations exhibit different mitofilin levels. Ferreira RM, et al. Cell Biochem Funct, 2012 Jul. PMID 22438066
  4. Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation. Navet R, et al. J Proteome Res, 2007 Jan. PMID 17203945
  5. Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms. Gieffers C, et al. Exp Cell Res, 1997 May 1. PMID 9168817

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage.
    Title: Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage.
  2. that altering levels of Mic60 in dopaminergic neuronal cells significantly affects both mitochondrial homeostasis and cellular vulnerability to the PD-relevant stressors dopamine and rotenone
    Title: Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone.
  3. The differential expression levels of mitofilin between IMF and SS also suggest that this protein can be used as a specific molecular marker to comparatively discriminate spatially distant mitochondrial populations.
    Title: Spatially distinct mitochondrial populations exhibit different mitofilin levels.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125092

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cristae formation IEA
Inferred from Electronic Annotation
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit Mic60
Names
inner membrane protein, mitochondrial
mitochondrial inner membrane protein
mitofilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034928.2 → NP_001030100.2  MICOS complex subunit Mic60

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5Y0P8
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 698
    Mitofilin; Mitochondrial inner membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    105438657..105477370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592625.3 → XP_017448114.2  MICOS complex subunit Mic60 isoform X8

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 726
    Mitofilin; Mitochondrial inner membrane protein

  2. XM_017592626.3 → XP_017448115.2  MICOS complex subunit Mic60 isoform X9

    UniProtKB/TrEMBL
    A0A140TAG5, A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 715
    Mitofilin; Mitochondrial inner membrane protein

  3. XM_039107573.2 → XP_038963501.1  MICOS complex subunit Mic60 isoform X12

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 698
    Mitofilin; Mitochondrial inner membrane protein

  4. XM_063286046.1 → XP_063142116.1  MICOS complex subunit Mic60 isoform X11

    UniProtKB/TrEMBL
    A6IA90

  5. XM_039107574.2 → XP_038963502.1  MICOS complex subunit Mic60 isoform X14

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 693
    Mitofilin; Mitochondrial inner membrane protein

  6. XM_039107576.2 → XP_038963504.1  MICOS complex subunit Mic60 isoform X17

    UniProtKB/TrEMBL
    A0A0G2JVH4, A0A8I6GLJ1
    Related
    ENSRNOP00000095249.1, ENSRNOT00000109981.2
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 709
    Mitofilin; Mitochondrial inner membrane protein

  7. XM_039107578.2 → XP_038963506.1  MICOS complex subunit Mic60 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JVH4
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 704
    Mitofilin; Mitochondrial inner membrane protein

  8. XM_008762989.4 → XP_008761211.1  MICOS complex subunit Mic60 isoform X23

    UniProtKB/TrEMBL
    A0A8I6ADG3
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 693
    Mitofilin; Mitochondrial inner membrane protein

  9. XM_017592623.3 → XP_017448112.2  MICOS complex subunit Mic60 isoform X3

    UniProtKB/TrEMBL
    A6IA90
    Related
    ENSRNOP00000090344.2, ENSRNOT00000098740.2
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 747
    Mitofilin; Mitochondrial inner membrane protein

  10. XM_063286045.1 → XP_063142115.1  MICOS complex subunit Mic60 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A9C1, A6IA90

  11. XM_008762985.4 → XP_008761207.1  MICOS complex subunit Mic60 isoform X15

    UniProtKB/TrEMBL
    A0A0G2JVH4
    Related
    ENSRNOP00000069486.3, ENSRNOT00000086291.3
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 725
    Mitofilin; Mitochondrial inner membrane protein

  12. XM_017592621.3 → XP_017448110.2  MICOS complex subunit Mic60 isoform X1

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 758
    Mitofilin; Mitochondrial inner membrane protein

  13. XM_039107572.2 → XP_038963500.1  MICOS complex subunit Mic60 isoform X5

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 741
    Mitofilin; Mitochondrial inner membrane protein

  14. XM_017592622.3 → XP_017448111.2  MICOS complex subunit Mic60 isoform X2

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 753
    Mitofilin; Mitochondrial inner membrane protein

  15. XM_063286044.1 → XP_063142114.1  MICOS complex subunit Mic60 isoform X6

    UniProtKB/TrEMBL
    A6IA90

  16. XM_017592624.3 → XP_017448113.2  MICOS complex subunit Mic60 isoform X4

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 746
    Mitofilin; Mitochondrial inner membrane protein

  17. XM_017592627.3 → XP_017448116.2  MICOS complex subunit Mic60 isoform X10

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 714
    Mitofilin; Mitochondrial inner membrane protein

  18. XM_017592628.3 → XP_017448117.2  MICOS complex subunit Mic60 isoform X16

    UniProtKB/TrEMBL
    A0A8I5Y0P8
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 684
    Mitofilin; Mitochondrial inner membrane protein

  19. XM_039107579.2 → XP_038963507.1  MICOS complex subunit Mic60 isoform X20

    UniProtKB/TrEMBL
    A0A8I5Y0P8
    Conserved Domains (1) summary
    pfam09731
    Location:43 → 667
    Mitofilin; Mitochondrial inner membrane protein

  20. XM_063286050.1 → XP_063142120.1  MICOS complex subunit Mic60 isoform X22

    UniProtKB/TrEMBL
    A0A8I5Y0P8

  21. XM_063286047.1 → XP_063142117.1  MICOS complex subunit Mic60 isoform X13

    UniProtKB/TrEMBL
    A0A0G2JVH4
    Related
    ENSRNOP00000051091.6, ENSRNOT00000043199.6

  22. XM_063286049.1 → XP_063142119.1  MICOS complex subunit Mic60 isoform X21

    UniProtKB/TrEMBL
    A0A8I5Y0P8

  23. XM_063286051.1 → XP_063142121.1  MICOS complex subunit Mic60 isoform X24

    UniProtKB/TrEMBL
    A0A8I5Y0P8
    Related
    ENSRNOP00000076735.1, ENSRNOT00000104257.2

  24. XM_039107577.2 → XP_038963505.1  MICOS complex subunit Mic60 isoform X18

    UniProtKB/TrEMBL
    A6IA90
    Conserved Domains (1) summary
    pfam09731
    Location:10 → 671
    Mitofilin; Mitochondrial inner membrane protein

  25. XM_063286048.1 → XP_063142118.1  MICOS complex subunit Mic60 isoform X18

    UniProtKB/TrEMBL
    A6IA90
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KR86.1 GenPept UniProtKB/Swiss-Prot:Q3KR86

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