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Mcm2 minichromosome maintenance complex component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312538, updated on 18-Sep-2024

Summary

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Official Symbol
Mcm2provided by RGD
Official Full Name
minichromosome maintenance complex component 2provided by RGD
Primary source
RGD:1305577
See related
EnsemblRapid:ENSRNOG00000016316 AllianceGenome:RGD:1305577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; enzyme binding activity; and histone binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in several processes, including DNA-dependent DNA replication; cochlea development; and double-strand break repair via break-induced replication. Predicted to act upstream of or within cellular response to interleukin-4 and nucleosome assembly. Located in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 288.6), Spleen (RPKM 187.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcm2 in Genome Data Viewer
Location:
4q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122903679..122918205, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121346434..121360962, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120825699..120840221, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB domain containing 1 Neighboring gene podocalyxin-like 2 Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene uncharacterized LOC102554942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Bonda DJ, et al. Aging (Albany NY), 2009 Apr. PMID 19946466, Free PMC Article
  2. Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusion. Sivilia S, et al. Neuropathol Appl Neurobiol, 2008 Feb. PMID 17931356
  3. Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene for Autosomal Dominant Nonsyndromic Deafness in a Chinese Family. Gao J, et al. PLoS One, 2015. PMID 26196677, Free PMC Article
  4. Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Zhang C, et al. Exp Neurol, 2007 Mar. PMID 17070803, Free PMC Article
  5. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. Chen JF, et al. J Neurosci, 1999 Nov 1. PMID 10531422, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
  
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA replication licensing factor MCM2
Names
minichromosome maintenance deficient 2 mitotin
NP_001101343.2
XP_006236925.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107873.2 → NP_001101343.2  DNA replication licensing factor MCM2

    See identical proteins and their annotated locations for NP_001101343.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3ZP96
    Related
    ENSRNOP00000022231.5, ENSRNOT00000022231.8
    Conserved Domains (4) summary
    smart00350
    Location:292 → 804
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:73 → 183
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:199 → 311
    MCM_N; MCM N-terminal domain
    cl21455
    Location:486 → 633
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    122903679..122918205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236863.3 → XP_006236925.1  DNA replication licensing factor MCM2 isoform X1

    See identical proteins and their annotated locations for XP_006236925.1

    UniProtKB/TrEMBL
    D3ZP96
    Conserved Domains (4) summary
    smart00350
    Location:292 → 804
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:73 → 183
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:199 → 311
    MCM_N; MCM N-terminal domain
    cl21455
    Location:486 → 633
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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