U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312566, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Adamts9provided by RGD
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 9provided by RGD
Primary source
RGD:1306889
See related
EnsemblRapid:ENSRNOG00000023257 AllianceGenome:RGD:1306889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Predicted to act upstream of or within camera-type eye development; positive regulation of melanocyte differentiation; and response to bacterium. Predicted to be located in cell surface; endoplasmic reticulum; and extracellular space. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 107.5), Lung (RPKM 85.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Adamts9 in Genome Data Viewer
Location:
4q34
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126847726..127019924, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (125290633..125462988, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124660254..124860997, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene prickle planar cell polarity protein 2 Neighboring gene uncharacterized LOC134486613 Neighboring gene uncharacterized LOC134486616 Neighboring gene uncharacterized LOC102554570 Neighboring gene uncharacterized LOC120102343 Neighboring gene uncharacterized LOC102555978 Neighboring gene uncharacterized LOC134486615 Neighboring gene uncharacterized LOC120102344

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Reid MJ, et al. Neurosci Lett, 2009 Mar 20. PMID 19348733
  2. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. Somerville RP, et al. J Biol Chem, 2003 Mar 14. PMID 12514189
  3. Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase. Dancevic CM, et al. J Biol Chem, 2013 Dec 27. PMID 24220035, Free PMC Article
  4. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Koo BH, et al. Am J Pathol, 2010 Mar. PMID 20093484, Free PMC Article
  5. Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Kern CB, et al. Matrix Biol, 2010 May. PMID 20096780, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study indicates that ADAMTS-9 expression is modulated in response to cerebral ischaemia in vivo
    Title: ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cornea development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lens development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 9
Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429136.1 → NP_001416065.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    126847726..127019924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286081.1 → XP_063142151.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X4

    Related
    ENSRNOP00000079368.2, ENSRNOT00000114542.2

  2. XM_063286077.1 → XP_063142147.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1

    Related
    ENSRNOP00000053878.4, ENSRNOT00000057045.4

  3. XM_063286078.1 → XP_063142148.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2

  4. XM_063286080.1 → XP_063142150.1  A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X3

RNA

  1. XR_010065646.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107877.1: Suppressed sequence

    Description
    NM_001107877.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools