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Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312574, updated on 2-Nov-2024

Summary

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Official Symbol
Lrig1provided by RGD
Official Full Name
leucine-rich repeats and immunoglobulin-like domains 1provided by RGD
Primary source
RGD:1306788
See related
EnsemblRapid:ENSRNOG00000012952 AllianceGenome:RGD:1306788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRIG1 (leucine rich repeats and immunoglobulin like domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 256.3), Muscle (RPKM 152.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrig1 in Genome Data Viewer
Location:
4q34
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (128687723..128788219, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (127130899..127230956, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (126615998..126717434, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102171 Neighboring gene proteasome 20S subunit alpha 3, pseudogene 3 Neighboring gene solute carrier family 25 member 26 Neighboring gene uncharacterized LOC134486819 Neighboring gene apolipoprotein O-like 2 Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling. Alsina FC, et al. EMBO Rep, 2016 Apr. PMID 26935556, Free PMC Article
  2. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article
  3. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within hair cycle process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within innervation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within otolith morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeats and immunoglobulin-like domains protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427801.1 → NP_001414730.1  leucine-rich repeats and immunoglobulin-like domains protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    M0RB60
    Related
    ENSRNOP00000066785.3, ENSRNOT00000072624.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    128687723..128788219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286082.1 → XP_063142152.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X1

  2. XM_039108763.2 → XP_038964691.1  leucine-rich repeats and immunoglobulin-like domains protein 1 isoform X2

    Conserved Domains (5) summary
    pfam01463
    Location:8 → 32
    LRRCT; Leucine rich repeat C-terminal domain
    pfam07679
    Location:235 → 322
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:36 → 123
    Ig_3; Immunoglobulin domain
    cd00096
    Location:243 → 246
    Ig; Ig strand A' [structural motif]
    cd05763
    Location:142 → 232
    IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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