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Mtmr14 myotubularin related protein 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312634, updated on 28-Oct-2024

Summary

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Official Symbol
Mtmr14provided by RGD
Official Full Name
myotubularin related protein 14provided by RGD
Primary source
RGD:1304842
See related
EnsemblRapid:ENSRNOG00000007881 AllianceGenome:RGD:1304842
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304842
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in perinuclear region of cytoplasm and ruffle. Human ortholog(s) of this gene implicated in centronuclear myopathy 1. Orthologous to human MTMR14 (myotubularin related protein 14). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 98.7), Liver (RPKM 79.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtmr14 in Genome Data Viewer
Location:
4q42
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (147942604..147985649)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146386949..146429990)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145195046..145238097)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 4 Neighboring gene uncharacterized LOC134486623 Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing, 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy. Tosch V, et al. Hum Mol Genet, 2006 Nov 1. PMID 17008356
  2. MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy. Pan Q, et al. Biochem Biophys Res Commun, 2020 Sep 3. PMID 32819563
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy.
    Title: MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myotubularin-related protein 14
NP_001101350.1
XP_006237086.1
XP_006237087.1
XP_006237088.1
XP_038963556.1
XP_038963558.1
XP_038963560.1
XP_038963561.1
XP_063142155.1
XP_063142156.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107880.1 → NP_001101350.1  myotubularin-related protein 14

    See identical proteins and their annotated locations for NP_001101350.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A0A8I5ZZY7, A6IBP6, D3ZMA2
    Related
    ENSRNOP00000010723.4, ENSRNOT00000010723.7
    Conserved Domains (1) summary
    cd13213
    Location:127 → 243
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    147942604..147985649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237024.5 → XP_006237086.1  myotubularin-related protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNW5, A0A8I5ZZY7
    Related
    ENSRNOP00000079859.1, ENSRNOT00000104597.2
    Conserved Domains (1) summary
    cd13213
    Location:127 → 243
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  2. XM_039107628.1 → XP_038963556.1  myotubularin-related protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZY7
    Related
    ENSRNOP00000094263.2, ENSRNOT00000114355.2
    Conserved Domains (2) summary
    cd13213
    Location:127 → 242
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cl28904
    Location:292 → 385
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_063286085.1 → XP_063142155.1  myotubularin-related protein 14 isoform X3

  4. XM_063286086.1 → XP_063142156.1  myotubularin-related protein 14 isoform X5

    Related
    ENSRNOP00000112530.1, ENSRNOT00000151766.1

  5. XM_039107630.1 → XP_038963558.1  myotubularin-related protein 14 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZZY7
    Conserved Domains (2) summary
    cd13213
    Location:127 → 243
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cl28904
    Location:293 → 386
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_039107632.1 → XP_038963560.1  myotubularin-related protein 14 isoform X7

    Conserved Domains (2) summary
    cd13213
    Location:127 → 243
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cl28904
    Location:293 → 386
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  7. XM_006237026.4 → XP_006237088.1  myotubularin-related protein 14 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AL76
    Conserved Domains (1) summary
    cd13213
    Location:7 → 123
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  8. XM_006237025.4 → XP_006237087.1  myotubularin-related protein 14 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AL76
    Conserved Domains (1) summary
    cd13213
    Location:31 → 147
    PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  9. XM_039107633.1 → XP_038963561.1  myotubularin-related protein 14 isoform X9

    Conserved Domains (2) summary
    cl17171
    Location:38 → 59
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:109 → 202
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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