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Creld1 cysteine-rich with EGF-like domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312638, updated on 2-Nov-2024

Summary

Official Symbol
Creld1provided by RGD
Official Full Name
cysteine-rich with EGF-like domains 1provided by RGD
Primary source
RGD:1309412
See related
EnsemblRapid:ENSRNOG00000009414 AllianceGenome:RGD:1309412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 133.6), Brain (RPKM 126.6) and 9 other tissues See more
Orthologs
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Genomic context

See Creld1 in Genome Data Viewer
Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148187510..148197120)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146631883..146641493)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145440284..145449894)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor E Neighboring gene interleukin 17 receptor C Neighboring gene proline-rich transmembrane protein 3 Neighboring gene ER membrane protein complex subunit 3 Neighboring gene FA complementation group D2 Neighboring gene FANCD2 opposite strand

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein disulfide isomerase Creld1
Names
cysteine-rich with EGF-like domain protein 1
NP_001019954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024783.1NP_001019954.1  protein disulfide isomerase Creld1 precursor

    See identical proteins and their annotated locations for NP_001019954.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097951
    UniProtKB/Swiss-Prot
    Q4V7F2
    UniProtKB/TrEMBL
    A6IBS5
    Related
    ENSRNOP00000013052.4, ENSRNOT00000013052.8
    Conserved Domains (4) summary
    smart00179
    Location:305337
    EGF_CA; Calcium-binding EGF-like domain
    smart00261
    Location:210245
    FU; Furin-like repeats
    pfam11938
    Location:46100
    DUF3456; TLR4 regulator and MIR-interacting MSAP
    cl21504
    Location:245272
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    148187510..148197120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)