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Art4 ADP-ribosyltransferase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312806, updated on 30-Mar-2024

Summary

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Official Symbol
Art4provided by RGD
Official Full Name
ADP-ribosyltransferase 4provided by RGD
Primary source
RGD:1306456
See related
Ensembl:ENSRNOG00000005670 AllianceGenome:RGD:1306456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ATR4
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Orthologous to human ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 130.5), Thymus (RPKM 130.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Art4 in Genome Data Viewer
Location:
4q43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171468415..171482435, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169740331..169751571, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170830851..170841187, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 11 Neighboring gene single-pass membrane protein with coiled-coil domains 3 like 1 Neighboring gene sorbitol dehydrogenase-like Neighboring gene similar to human chromosome 12 open reading frame 60 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Glowacki G, et al. Protein Sci, 2002 Jul. PMID 12070318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 4
Names
ADP-ribosyltransferase 4 (Dombrock blood group)
NAD(P)(+)--arginine ADP-ribosyltransferase
NP_001166980.1
XP_038963627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173509.1 → NP_001166980.1  ecto-ADP-ribosyltransferase 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IMI9, F1MA10
    Related
    ENSRNOP00000007485.4, ENSRNOT00000007485.6
    Conserved Domains (1) summary
    cl00173
    Location:41 → 261
    VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    171468415..171482435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107699.2 → XP_038963627.1  ecto-ADP-ribosyltransferase 4 isoform X1

    UniProtKB/TrEMBL
    A6IMI9
    Conserved Domains (1) summary
    cl00173
    Location:37 → 257
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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