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Ppfibp1 PPFIA binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312855, updated on 17-Aug-2024

Summary

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Official Symbol
Ppfibp1provided by RGD
Official Full Name
PPFIA binding protein 1provided by RGD
Primary source
RGD:1310010
See related
EnsemblRapid:ENSRNOG00000031709 AllianceGenome:RGD:1310010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in neuromuscular junction development. Predicted to be active in presynaptic active zone. Orthologous to human PPFIBP1 (PPFIA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 358.7), Kidney (RPKM 263.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q44
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181538249..181682079)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179807579..179951428)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (181285179..181428157)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene similar to human chromosome 12 open reading frame 71 Neighboring gene high mobility group protein B1-like Neighboring gene RAB15 effector protein Neighboring gene mitochondrial ribosomal protein S35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
liprin-beta-1
Names
PTPRF interacting protein, binding protein 1 (liprin beta 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395638.1 → NP_001382567.1  liprin-beta-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K781
    Conserved Domains (4) summary
    cd09563
    Location:613 → 676
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:687 → 749
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:772 → 843
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:47 → 310
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    181538249..181682079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763382.3 → XP_008761604.1  liprin-beta-1 isoform X1

    See identical proteins and their annotated locations for XP_008761604.1

    UniProtKB/TrEMBL
    A0A0G2K781, A0A8I6ANB2
    Conserved Domains (5) summary
    cd09563
    Location:666 → 729
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:740 → 802
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:825 → 896
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PHA03307
    Location:383 → 648
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:100 → 352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_063286177.1 → XP_063142247.1  liprin-beta-1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K781, A0A8I6ATF2

  3. XM_063286181.1 → XP_063142251.1  liprin-beta-1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K781
    Related
    ENSRNOP00000097266.2, ENSRNOT00000115987.2

  4. XM_063286179.1 → XP_063142249.1  liprin-beta-1 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K781

  5. XM_063286183.1 → XP_063142253.1  liprin-beta-1 isoform X10

    UniProtKB/TrEMBL
    A0A0G2K781
    Related
    ENSRNOP00000093133.2, ENSRNOT00000094198.2

  6. XM_063286186.1 → XP_063142256.1  liprin-beta-1 isoform X13

    UniProtKB/TrEMBL
    A0A0G2K781, A0A8I6AGP2

  7. XM_063286188.1 → XP_063142258.1  liprin-beta-1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2K781

  8. XM_063286189.1 → XP_063142259.1  liprin-beta-1 isoform X16

    UniProtKB/TrEMBL
    A6IN37
    Related
    ENSRNOP00000039655.4, ENSRNOT00000044147.5

  9. XM_039107707.2 → XP_038963635.1  liprin-beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K781, A0A8I6ANB2
    Conserved Domains (5) summary
    cd09563
    Location:666 → 729
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:740 → 802
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:825 → 896
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PHA03307
    Location:383 → 648
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:100 → 352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. XM_039107711.2 → XP_038963639.1  liprin-beta-1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K781
    Conserved Domains (4) summary
    cd09563
    Location:655 → 718
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:729 → 791
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:814 → 885
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:100 → 352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_039107710.2 → XP_038963638.1  liprin-beta-1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K781
    Related
    ENSRNOP00000096890.2, ENSRNOT00000098646.2
    Conserved Domains (5) summary
    cd09563
    Location:656 → 719
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:730 → 792
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:815 → 886
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PHA03307
    Location:383 → 638
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:100 → 352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_039107713.2 → XP_038963641.1  liprin-beta-1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K781, A0A8I6ATF2
    Conserved Domains (4) summary
    cd09563
    Location:645 → 708
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:719 → 781
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:804 → 875
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:100 → 352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. XM_039107712.2 → XP_038963640.1  liprin-beta-1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K781
    Conserved Domains (5) summary
    cd09563
    Location:655 → 718
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:729 → 791
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:814 → 885
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PHA03307
    Location:372 → 637
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:47 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. XM_039107719.2 → XP_038963647.1  liprin-beta-1 isoform X17

    UniProtKB/TrEMBL
    A0A0G2K781
    Conserved Domains (4) summary
    cd09563
    Location:644 → 707
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:718 → 780
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:803 → 874
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:47 → 341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  15. XM_063286178.1 → XP_063142248.1  liprin-beta-1 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K781
    Related
    ENSRNOP00000074098.2, ENSRNOT00000083633.3

  16. XM_063286180.1 → XP_063142250.1  liprin-beta-1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K781

  17. XM_039107714.2 → XP_038963642.1  liprin-beta-1 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K781
    Conserved Domains (5) summary
    cd09563
    Location:635 → 698
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:709 → 771
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:794 → 865
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PHA03307
    Location:352 → 617
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:47 → 321
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  18. XM_063286184.1 → XP_063142254.1  liprin-beta-1 isoform X11

    UniProtKB/TrEMBL
    A0A0G2K781

  19. XM_063286182.1 → XP_063142252.1  liprin-beta-1 isoform X10

    UniProtKB/TrEMBL
    A0A0G2K781

  20. XM_039107716.2 → XP_038963644.1  liprin-beta-1 isoform X13

    UniProtKB/TrEMBL
    A0A0G2K781, A0A8I6AGP2
    Conserved Domains (4) summary
    cd09563
    Location:614 → 677
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:688 → 750
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:773 → 844
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:47 → 321
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  21. XM_039107715.2 → XP_038963643.1  liprin-beta-1 isoform X12

    UniProtKB/TrEMBL
    A0A0G2K781
    Related
    ENSRNOP00000110979.1, ENSRNOT00000170543.1
    Conserved Domains (5) summary
    cd09563
    Location:624 → 687
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:698 → 760
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:783 → 854
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    PHA03307
    Location:341 → 606
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:47 → 310
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  22. XM_039107717.2 → XP_038963645.1  liprin-beta-1 isoform X15

    UniProtKB/TrEMBL
    A0A0G2K781
    Conserved Domains (4) summary
    cd09563
    Location:613 → 676
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:687 → 749
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:772 → 843
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:47 → 310
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  23. XM_063286187.1 → XP_063142257.1  liprin-beta-1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2K781

  24. XM_039107718.2 → XP_038963646.1  liprin-beta-1 isoform X16

    UniProtKB/TrEMBL
    A6IN37
    Conserved Domains (4) summary
    cd09563
    Location:603 → 666
    SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
    cd09566
    Location:677 → 739
    SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
    cd09569
    Location:762 → 833
    SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
    COG1196
    Location:47 → 310
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  25. XM_063286176.1 → XP_063142246.1  liprin-beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K781

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107896.1: Suppressed sequence

    Description
    NM_001107896.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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