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Slco5a1 solute carrier organic anion transporter family, member 5A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312907, updated on 2-Nov-2024

Summary

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Official Symbol
Slco5a1provided by RGD
Official Full Name
solute carrier organic anion transporter family, member 5A1provided by RGD
Primary source
RGD:1307132
See related
EnsemblRapid:ENSRNOG00000008966 AllianceGenome:RGD:1307132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO5A1 (solute carrier organic anion transporter family member 5A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 107.6), Heart (RPKM 60.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slco5a1 in Genome Data Viewer
Location:
5q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (11012001..11141180)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (6228938..6358124)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (5866362..5994748)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene PR/SET domain 14 Neighboring gene U6 spliceosomal RNA Neighboring gene sulfatase 1 Neighboring gene uncharacterized LOC120102810 Neighboring gene ATPase H+ transporting V1 subunit E1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. Kindla J, et al. Cancer Biol Ther, 2011 Mar 15. PMID 21278488
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 5A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107898.1 → NP_001101368.1  solute carrier organic anion transporter family member 5A1

    See identical proteins and their annotated locations for NP_001101368.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473984
    UniProtKB/TrEMBL
    A0A8I6A406, A6JFD8
    Related
    ENSRNOP00000082764.1, ENSRNOT00000113639.2
    Conserved Domains (3) summary
    cd06174
    Location:134 → 532
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:544 → 598
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:132 → 727
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    11012001..11141180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109745.2 → XP_038965673.1  solute carrier organic anion transporter family member 5A1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A406
    Related
    ENSRNOP00000077674.2, ENSRNOT00000118060.2
    Conserved Domains (1) summary
    cd17404
    Location:131 → 621
    MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

  2. XM_008763495.4 → XP_008761717.1  solute carrier organic anion transporter family member 5A1 isoform X1

    See identical proteins and their annotated locations for XP_008761717.1

    UniProtKB/TrEMBL
    A0A8I6A406, D3ZZM7
    Related
    ENSRNOP00000011940.5, ENSRNOT00000011940.7
    Conserved Domains (1) summary
    cd17404
    Location:131 → 676
    MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

  3. XM_039109744.2 → XP_038965672.1  solute carrier organic anion transporter family member 5A1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A406, D3ZZM7
    Conserved Domains (1) summary
    cd17404
    Location:131 → 676
    MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

  4. XM_039109746.1 → XP_038965674.1  solute carrier organic anion transporter family member 5A1 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:21 → 264
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version

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