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Map3k6 mitogen-activated protein kinase kinase kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313022, updated on 2-Nov-2024

Summary

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Official Symbol
Map3k6provided by RGD
Official Full Name
mitogen-activated protein kinase kinase kinase 6provided by RGD
Primary source
RGD:1304625
See related
EnsemblRapid:ENSRNOG00000008936 AllianceGenome:RGD:1304625
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in JNK cascade; p38MAPK cascade; and protein phosphorylation. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 29.3), Adrenal (RPKM 16.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Map3k6 in Genome Data Viewer
Location:
5q36
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150724029..150736113)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145440126..145452213)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151435679..151448329)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 3 Neighboring gene CD164 molecule like 2 Neighboring gene synaptotagmin-like 1 Neighboring gene transmembrane protein 222 Neighboring gene uncharacterized LOC134487005

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. Wang XS, et al. Biochem Biophys Res Commun, 1998 Dec 9. PMID 9875215
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 6
NP_001101379.1
XP_006239081.1
XP_006239082.1
XP_006239084.1
XP_008762359.1
XP_038965707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107909.1 → NP_001101379.1  mitogen-activated protein kinase kinase kinase 6

    See identical proteins and their annotated locations for NP_001101379.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6ISW1, D3ZFL3
    Related
    ENSRNOP00000012463.5, ENSRNOT00000012463.7
    Conserved Domains (3) summary
    smart00220
    Location:654 → 907
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:640 → 907
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130 → 507
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150724029..150736113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239020.5 → XP_006239082.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:646 → 899
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:632 → 899
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130 → 499
    DUF4071; Domain of unknown function (DUF4071)

  2. XM_006239019.5 → XP_006239081.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:654 → 907
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:640 → 907
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130 → 507
    DUF4071; Domain of unknown function (DUF4071)

  3. XM_008764137.4 → XP_008762359.1  mitogen-activated protein kinase kinase kinase 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZR53
    Related
    ENSRNOP00000080621.1, ENSRNOT00000093926.2
    Conserved Domains (3) summary
    smart00220
    Location:646 → 899
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:632 → 899
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:130 → 499
    DUF4071; Domain of unknown function (DUF4071)

  4. XM_039109779.2 → XP_038965707.1  mitogen-activated protein kinase kinase kinase 6 isoform X4

    Conserved Domains (3) summary
    cd06624
    Location:432 → 699
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:24 → 300
    DUF4071; Domain of unknown function (DUF4071)
    pfam19039
    Location:316 → 406
    ASK_PH; ASK kinase PH domain

  5. XM_006239022.5 → XP_006239084.1  mitogen-activated protein kinase kinase kinase 6 isoform X4

    Conserved Domains (3) summary
    cd06624
    Location:432 → 699
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:24 → 300
    DUF4071; Domain of unknown function (DUF4071)
    pfam19039
    Location:316 → 406
    ASK_PH; ASK kinase PH domain
Nucleotide Protein Strain
Heading Accession and Version

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