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Wasf2 WASP family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313024, updated on 28-Oct-2024

Summary

Official Symbol
Wasf2provided by RGD
Official Full Name
WASP family member 2provided by RGD
Primary source
RGD:1307299
See related
EnsemblRapid:ENSRNOG00000009805 AllianceGenome:RGD:1307299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SH3 domain binding activity and protein kinase A binding activity. Predicted to be involved in negative regulation of stress fiber assembly; positive regulation of lamellipodium assembly; and postsynaptic actin cytoskeleton organization. Predicted to act upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Predicted to be located in several cellular components, including early endosome; lamellipodium; and ruffle. Predicted to be part of SCAR complex. Predicted to be active in synapse. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 131.6), Spleen (RPKM 127.2) and 9 other tissues See more
Orthologs
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Genomic context

See Wasf2 in Genome Data Viewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150620733..150685943)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145336817..145402041)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151319382..151385051)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351145 Neighboring gene FGR proto-oncogene, Src family tyrosine kinase Neighboring gene AT hook, DNA binding motif, containing 1 Neighboring gene uncharacterized LOC120102997 Neighboring gene CD164 molecule like 2 Neighboring gene G protein-coupled receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105905

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin-binding protein WASF2
Names
WAS protein family, member 2
wiskott-Aldrich syndrome protein family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013167.2NP_001013185.1  actin-binding protein WASF2

    See identical proteins and their annotated locations for NP_001013185.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K5T9, E9PTF9, Q5FWU0
    Conserved Domains (2) summary
    cd21762
    Location:449452
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:427478
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
  2. NM_001394051.1NP_001380980.1  actin-binding protein WASF2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K5T9, E9PTF9, Q5FWU0
    Related
    ENSRNOP00000063111.4, ENSRNOT00000067801.5
    Conserved Domains (2) summary
    cd21762
    Location:449452
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:427478
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150620733..150685943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109782.2XP_038965710.1  actin-binding protein WASF2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5T9, E9PTF9, Q5FWU0
    Conserved Domains (2) summary
    cd21762
    Location:449452
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:427478
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
  2. XM_039109783.2XP_038965711.1  actin-binding protein WASF2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5T9, E9PTF9, Q5FWU0
    Conserved Domains (2) summary
    cd21762
    Location:449452
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:427478
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
  3. XM_039109781.2XP_038965709.1  actin-binding protein WASF2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5T9, E9PTF9, Q5FWU0
    Conserved Domains (2) summary
    cd21762
    Location:449452
    WH2; actin-binding sequence [structural motif]
    cl41728
    Location:427478
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins