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Ppp1r8 protein phosphatase 1, regulatory subunit 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313030, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp1r8provided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 8provided by RGD
Primary source
RGD:1306280
See related
EnsemblRapid:ENSRNOG00000059550 AllianceGenome:RGD:1306280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity and protein serine/threonine phosphatase inhibitor activity. Predicted to act upstream of or within cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 128.2), Adrenal (RPKM 118.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r8 in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150315607..150332726, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145031632..145048753, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151012035..151029227, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102994 Neighboring gene SWI5 homologous recombination repair protein like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene small Cajal body-specific RNA 1 Neighboring gene syntaxin 12 Neighboring gene family with sequence similarity 76, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Van Eynde A, et al. Mol Cell Biol, 2004 Jul. PMID 15199142, Free PMC Article
  2. Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. Trinkle-Mulcahy L, et al. J Cell Sci, 2001 Dec. PMID 11739654
  3. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. Boudrez A, et al. J Biol Chem, 2000 Aug 18. PMID 10827081
  4. SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Llorian M, et al. Biochem J, 2004 Feb 15. PMID 14640981, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear inhibitor of protein phosphatase 1
Names
protein phosphatase 1, regulatory (inhibitor) subunit 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107911.1 → NP_001101381.1  nuclear inhibitor of protein phosphatase 1

    See identical proteins and their annotated locations for NP_001101381.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A0A0G2JWS4, A6ISV1, B1WC70
    Related
    ENSRNOP00000069996.2, ENSRNOT00000089155.3
    Conserved Domains (3) summary
    COG1716
    Location:41 → 151
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:27 → 119
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam11945
    Location:98 → 212
    WASH_WAHD; WAHD domain of WASH complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150315607..150332726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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