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Epb41 erythrocyte membrane protein band 4.1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313052, updated on 28-Oct-2024

Summary

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Official Symbol
Epb41provided by RGD
Official Full Name
erythrocyte membrane protein band 4.1provided by RGD
Primary source
RGD:1564762
See related
EnsemblRapid:ENSRNOG00000010037 AllianceGenome:RGD:1564762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Epb4.1; RGD1564762
Summary
Enables actin binding activity and spectrin binding activity. Involved in protein-containing complex assembly. Located in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Spleen (RPKM 422.3), Kidney (RPKM 205.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Epb41 in Genome Data Viewer
Location:
5q36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149394080..149548178, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144110010..144264037, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150081727..150243186, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene transmembrane protein 200B Neighboring gene opioid receptor, delta 1 Neighboring gene YTH N6-methyladenosine RNA binding protein F2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein 4.1 in forebrain postsynaptic density preparations: enrichment of 4.1 gene products and detection of 4.1R binding proteins. Scott C, et al. Eur J Biochem, 2001 Feb. PMID 11179975
  2. Immunolocalization of protein 4.1B in the rat digestive system. Terada N, et al. J Mol Histol, 2004 May. PMID 15503808
  3. Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene. Dalla Venezia N, et al. J Clin Invest, 1992 Nov. PMID 1430200, Free PMC Article
  4. Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability. Tchernia G, et al. J Clin Invest, 1981 Aug. PMID 6894932, Free PMC Article
  5. Paranodin, a glycoprotein of neuronal paranodal membranes. Menegoz M, et al. Neuron, 1997 Aug. PMID 9292722

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables spectrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intestinal absorption ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein 4.1
Names
erythrocyte protein band 4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399558.1 → NP_001386487.1  protein 4.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    149394080..149548178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287563.1 → XP_063143633.1  protein 4.1 isoform X40

  2. XM_063287556.1 → XP_063143626.1  protein 4.1 isoform X33

  3. XM_063287555.1 → XP_063143625.1  protein 4.1 isoform X32

  4. XM_063287546.1 → XP_063143616.1  protein 4.1 isoform X22

  5. XM_063287551.1 → XP_063143621.1  protein 4.1 isoform X28

  6. XM_063287548.1 → XP_063143618.1  protein 4.1 isoform X25

  7. XM_063287554.1 → XP_063143624.1  protein 4.1 isoform X31

  8. XM_063287549.1 → XP_063143619.1  protein 4.1 isoform X26

  9. XM_063287550.1 → XP_063143620.1  protein 4.1 isoform X27

  10. XM_063287552.1 → XP_063143622.1  protein 4.1 isoform X29

  11. XM_063287567.1 → XP_063143637.1  protein 4.1 isoform X44

  12. XM_063287562.1 → XP_063143632.1  protein 4.1 isoform X39

  13. XM_063287558.1 → XP_063143628.1  protein 4.1 isoform X35

  14. XM_063287568.1 → XP_063143638.1  protein 4.1 isoform X45

  15. XM_063287565.1 → XP_063143635.1  protein 4.1 isoform X42

  16. XM_063287573.1 → XP_063143643.1  protein 4.1 isoform X50

  17. XM_063287566.1 → XP_063143636.1  protein 4.1 isoform X43

  18. XM_063287560.1 → XP_063143630.1  protein 4.1 isoform X37

  19. XM_063287570.1 → XP_063143640.1  protein 4.1 isoform X47

  20. XM_063287572.1 → XP_063143642.1  protein 4.1 isoform X49

  21. XM_063287557.1 → XP_063143627.1  protein 4.1 isoform X34

  22. XM_063287571.1 → XP_063143641.1  protein 4.1 isoform X48

  23. XM_063287561.1 → XP_063143631.1  protein 4.1 isoform X38

  24. XM_063287564.1 → XP_063143634.1  protein 4.1 isoform X41

  25. XM_063287559.1 → XP_063143629.1  protein 4.1 isoform X36

  26. XM_063287569.1 → XP_063143639.1  protein 4.1 isoform X46

  27. XM_039111260.1 → XP_038967188.1  protein 4.1 isoform X17

    UniProtKB/TrEMBL
    D4A9A6
    Conserved Domains (5) summary
    smart00295
    Location:210 → 400
    B41; Band 4.1 homologues
    cd13184
    Location:395 → 488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:605 → 651
    SAB; SAB domain
    pfam05902
    Location:690 → 796
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:498 → 541
    FA; FERM adjacent (FA)

  28. XM_063287545.1 → XP_063143615.1  protein 4.1 isoform X19

  29. XM_063287542.1 → XP_063143612.1  protein 4.1 isoform X10

  30. XM_063287547.1 → XP_063143617.1  protein 4.1 isoform X24

  31. XM_017593842.1 → XP_017449331.1  protein 4.1 isoform X16

    UniProtKB/TrEMBL
    D3ZKF7, D4A9A6
    Related
    ENSRNOP00000061387.2, ENSRNOT00000067349.6

  32. XM_063287544.1 → XP_063143614.1  protein 4.1 isoform X14

  33. XM_063287543.1 → XP_063143613.1  protein 4.1 isoform X13

  34. XM_017593843.1 → XP_017449332.1  protein 4.1 isoform X18

    UniProtKB/TrEMBL
    A0A8I6A4E3

  35. XM_063287540.1 → XP_063143610.1  protein 4.1 isoform X5

  36. XM_063287539.1 → XP_063143609.1  protein 4.1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y1T6
    Related
    ENSRNOP00000077988.1, ENSRNOT00000107222.2

  37. XM_017593838.1 → XP_017449327.1  protein 4.1 isoform X11

    UniProtKB/TrEMBL
    D4A9A6

  38. XM_063287538.1 → XP_063143608.1  protein 4.1 isoform X3

  39. XM_039111259.1 → XP_038967187.1  protein 4.1 isoform X15

    UniProtKB/TrEMBL
    D4A9A6
    Conserved Domains (5) summary
    smart00295
    Location:210 → 400
    B41; Band 4.1 homologues
    cd13184
    Location:395 → 488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:658 → 706
    SAB; SAB domain
    pfam05902
    Location:720 → 808
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:498 → 541
    FA; FERM adjacent (FA)

  40. XM_017593839.1 → XP_017449328.1  protein 4.1 isoform X12

    UniProtKB/TrEMBL
    A0A8I6A4E3
    Related
    ENSRNOP00000085800.2, ENSRNOT00000112187.2

  41. XM_017593836.1 → XP_017449325.1  protein 4.1 isoform X9

    UniProtKB/TrEMBL
    D3ZIP3, D4A9A6
    Related
    ENSRNOP00000075428.3, ENSRNOT00000079935.3

  42. XM_017593830.1 → XP_017449319.1  protein 4.1 isoform X2

    UniProtKB/TrEMBL
    A6ISR5

  43. XM_017593835.1 → XP_017449324.1  protein 4.1 isoform X8

    UniProtKB/TrEMBL
    D4A9A6
    Related
    ENSRNOP00000013761.5, ENSRNOT00000013761.8

  44. XM_017593827.1 → XP_017449316.1  protein 4.1 isoform X1

    UniProtKB/TrEMBL
    A6ISR5

  45. XM_063287541.1 → XP_063143611.1  protein 4.1 isoform X6

  46. XM_017593834.1 → XP_017449323.1  protein 4.1 isoform X7

    UniProtKB/TrEMBL
    D4A9A6

  47. XM_039111264.2 → XP_038967192.1  protein 4.1 isoform X21

    UniProtKB/TrEMBL
    A0A0G2K161
    Conserved Domains (4) summary
    smart00295
    Location:210 → 400
    B41; Band 4.1 homologues
    cd13184
    Location:395 → 488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:657 → 705
    SAB; SAB domain
    pfam08736
    Location:498 → 541
    FA; FERM adjacent (FA)

  48. XM_063287553.1 → XP_063143623.1  protein 4.1 isoform X30

  49. XM_039111265.2 → XP_038967193.1  protein 4.1 isoform X23

    UniProtKB/TrEMBL
    A0A0G2K161
    Conserved Domains (4) summary
    smart00295
    Location:210 → 400
    B41; Band 4.1 homologues
    cd13184
    Location:395 → 488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:658 → 706
    SAB; SAB domain
    pfam08736
    Location:498 → 541
    FA; FERM adjacent (FA)

  50. XM_039111263.2 → XP_038967191.1  protein 4.1 isoform X20

    UniProtKB/TrEMBL
    A0A0G2K161
    Related
    ENSRNOP00000071712.3, ENSRNOT00000088493.3
    Conserved Domains (4) summary
    smart00295
    Location:210 → 400
    B41; Band 4.1 homologues
    cd13184
    Location:395 → 488
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:658 → 706
    SAB; SAB domain
    pfam08736
    Location:498 → 541
    FA; FERM adjacent (FA)
Nucleotide Protein Strain
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