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Trim14 tripartite motif-containing 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313236, updated on 2-Nov-2024

Summary

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Official Symbol
Trim14provided by RGD
Official Full Name
tripartite motif-containing 14provided by RGD
Primary source
RGD:1311514
See related
EnsemblRapid:ENSRNOG00000008922 AllianceGenome:RGD:1311514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including innate immune response; negative regulation of viral transcription; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm. Orthologous to human TRIM14 (tripartite motif containing 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 68.8), Testes (RPKM 56.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trim14 in Genome Data Viewer
Location:
5q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65596149..65620434, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60800568..60824858, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (62128941..62154424, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene N-acetylneuraminate synthase Neighboring gene coronin 2A Neighboring gene uncharacterized LOC108350963 Neighboring gene uncharacterized LOC108350962 Neighboring gene TBC1 domain family, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis. Xie X, et al. J Recept Signal Transduct Res, 2022 Apr. PMID 33691569
  2. Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice. Hou H, et al. Mol Med Rep, 2023 Sep. PMID 37503784, Free PMC Article
  3. RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14. Lv R, et al. Int Immunopharmacol, 2023 Dec. PMID 37951197
  4. Trim14-IκBα Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients. Niu Z, et al. Neuroscience, 2024 Jun 7. PMID 38697463
  5. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. Uchil PD, et al. J Virol, 2013 Jan. PMID 23077300, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
    Title: Trim14-IκBα Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
  2. RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/beta-catenin signaling pathway through degrading TRIM14.
    Title: RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14.
  3. Tripartite motif-containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
    Title: Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
  4. Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-kappaB/NLRP3 pathway-mediated inflammation and apoptosis.
    Title: Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 14
Names
tripartite motif protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107934.3 → NP_001101404.1  tripartite motif-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001101404.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IJC4, D3ZBI1
    Related
    ENSRNOP00000111077.1, ENSRNOT00000159497.1
    Conserved Domains (2) summary
    pfam00643
    Location:20 → 56
    zf-B_box; B-box zinc finger
    cd13738
    Location:204 → 376
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  2. NM_001399174.2 → NP_001386103.1  tripartite motif-containing protein 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    B2RYH2
    Related
    ENSRNOP00000088241.1, ENSRNOT00000107290.2
    Conserved Domains (2) summary
    cd13738
    Location:267 → 439
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
    cd19768
    Location:20 → 63
    Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    65596149..65620434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238062.5 → XP_006238124.1  tripartite motif-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006238124.1

    Conserved Domains (1) summary
    cd13738
    Location:198 → 370
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  2. XM_006238061.4 → XP_006238123.1  tripartite motif-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006238123.1

    Conserved Domains (1) summary
    cd13738
    Location:198 → 370
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  3. XM_039109868.2 → XP_038965796.1  tripartite motif-containing protein 14 isoform X2

    Conserved Domains (1) summary
    cd13738
    Location:112 → 284
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

  4. XM_039109869.2 → XP_038965797.1  tripartite motif-containing protein 14 isoform X2

    Conserved Domains (1) summary
    cd13738
    Location:112 → 284
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
Nucleotide Protein Strain
Heading Accession and Version

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