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Kif12 kinesin family member 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313254, updated on 18-Sep-2024

Summary

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Official Symbol
Kif12provided by RGD
Official Full Name
kinesin family member 12provided by RGD
Primary source
RGD:1308487
See related
EnsemblRapid:ENSRNOG00000007080 AllianceGenome:RGD:1308487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in extracellular exosome and microtubule organizing center. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 736.0) See more
Orthologs
human mouse all
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Genomic context

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See Kif12 in Genome Data Viewer
Location:
5q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81611730..81620977, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76596204..76603261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (79001708..79008370, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 618 Neighboring gene alpha-1-microglobulin/bikunin precursor Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455 Neighboring gene orosomucoid 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development. Courtois A, et al. J Cell Biol, 2012 Aug 6. PMID 22851319, Free PMC Article
  2. Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Zhang Y, et al. Electrophoresis, 2010 Dec. PMID 21082674
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012102.2 → NP_001012102.2  kinesin-like protein KIF12

    See identical proteins and their annotated locations for NP_001012102.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6J7X5
    Conserved Domains (3) summary
    cd00106
    Location:25 → 363
    KISc; Kinesin motor domain
    pfam00225
    Location:31 → 365
    Kinesin; Kinesin motor domain
    pfam12711
    Location:384 → 469
    Kinesin-relat_1; Kinesin motor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    81611730..81620977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238253.5 → XP_006238315.1  kinesin-like protein KIF12 isoform X1

    UniProtKB/TrEMBL
    G3V6Y3
    Related
    ENSRNOP00000010040.5, ENSRNOT00000010040.7
    Conserved Domains (3) summary
    cd00106
    Location:25 → 363
    KISc; Kinesin motor domain
    pfam00225
    Location:31 → 365
    Kinesin; Kinesin motor domain
    pfam12711
    Location:384 → 469
    Kinesin-relat_1; Kinesin motor

  2. XM_063287632.1 → XP_063143702.1  kinesin-like protein KIF12 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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