Megf9 multiple EGF-like-domains 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Megf9provided by RGD
Official Full Name: multiple EGF-like-domains 9provided by RGD
Primary source: RGD:1308330
See related: EnsemblRapid:ENSRNOG00000005932 AllianceGenome:RGD:1308330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Egfl5
Summary: Predicted to be involved in several processes, including animal organ morphogenesis; cell migration; and substrate adhesion-dependent cell spreading. Predicted to be integral component of membrane. Predicted to be active in basement membrane. Orthologous to human MEGF9 (multiple EGF like domains 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 181.2), Lung (RPKM 113.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (89008679..89120731, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (83993565..84105622, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (86586996..86696388, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multiple epidermal growth factor-like domains protein 9

Names: EGF-like-domain, multiple 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107940.1 → NP_001101410.1 multiple epidermal growth factor-like domains protein 9 precursor

See identical proteins and their annotated locations for NP_001101410.1

Status: PROVISIONAL

Source sequence(s)

CH473978

UniProtKB/TrEMBL

A6J807, D4A3L3

Related

ENSRNOP00000007812.4, ENSRNOT00000007812.6

Conserved Domains (3) summary

cd00055
Location:297 → 343

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:251 → 298

Laminin_EGF; Laminin EGF domain

cl01294
Location:54 → 175

Baseplate_J; Baseplate J-like protein