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Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313409, updated on 10-Oct-2024

Summary

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Official Symbol
Dnajc6provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C6provided by RGD
Primary source
RGD:1309900
See related
EnsemblRapid:ENSRNOG00000052887 AllianceGenome:RGD:1309900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatase activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to act upstream of or within clathrin coat disassembly and regulation of clathrin-dependent endocytosis. Predicted to be located in postsynaptic density. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 363.6), Kidney (RPKM 45.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Dnajc6 in Genome Data Viewer
Location:
5q33
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (121232532..121398775)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116120069..116283448)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120330372..120492515)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479017 Neighboring gene adenylate kinase 4 Neighboring gene uncharacterized LOC134479018 Neighboring gene uncharacterized LOC120102936 Neighboring gene leptin receptor overlapping transcript Neighboring gene leptin receptor Neighboring gene oogenesin 3, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin. Rothnie A, et al. Proc Natl Acad Sci U S A, 2011 Apr 26. PMID 21482805, Free PMC Article
  2. Multiple roles for cyclin G-associated kinase in clathrin-mediated sorting events. Zhang CX, et al. Traffic, 2005 Dec. PMID 16262722
  3. Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms. Drouet V, et al. Biomed Res Int, 2014. PMID 25302295, Free PMC Article
  4. MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating. Scott H, et al. J Biol Chem, 2012 Apr 27. PMID 22393045, Free PMC Article
  5. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, et al. Trends Neurosci, 2015 Mar. PMID 25639775, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-3120 was found to be located in neuronal cell bodies and to target Hsc70 and auxilin, and its lentivirus-mediated expression inhibited the uncoating of clathrin-coated vesicles.
    Title: MiR-3120 is a mirror microRNA that targets heat shock cognate protein 70 and auxilin messenger RNAs and regulates clathrin vesicle uncoating.
  2. A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin.
    Title: A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within clathrin coat disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle uncoating ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative tyrosine-protein phosphatase auxilin
Names
DnaJ (Hsp40) homolog, subfamily C, member 6
NP_001402850.1
XP_006238509.3
XP_006238510.1
XP_006238511.1
XP_038965846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415921.1 → NP_001402850.1  putative tyrosine-protein phosphatase auxilin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AMT9
    Related
    ENSRNOP00000095523.1, ENSRNOT00000113921.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    121232532..121398775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238447.5 → XP_006238509.3  putative tyrosine-protein phosphatase auxilin isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWX0, A0A8I6A6P4
    Conserved Domains (4) summary
    cd06257
    Location:892 → 937
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    PHA03247
    Location:565 → 796
    PHA03247; large tegument protein UL36; Provisional
    cd14563
    Location:87 → 249
    PTP_auxilin_N; N-terminal protein tyrosine phosphatase-like domain of auxilin
    pfam10409
    Location:257 → 395
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  2. XM_039109918.2 → XP_038965846.1  putative tyrosine-protein phosphatase auxilin isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZWX0
    Related
    ENSRNOP00000109452.1, ENSRNOT00000130808.1
    Conserved Domains (4) summary
    cd06257
    Location:848 → 893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    PHA03247
    Location:521 → 752
    PHA03247; large tegument protein UL36; Provisional
    cd14563
    Location:43 → 205
    PTP_auxilin_N; N-terminal protein tyrosine phosphatase-like domain of auxilin
    pfam10409
    Location:213 → 351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  3. XM_006238448.5 → XP_006238510.1  putative tyrosine-protein phosphatase auxilin isoform X2

    UniProtKB/TrEMBL
    A0A0G2JY26, A6JRN8, D4A0I5
    Related
    ENSRNOP00000070493.1, ENSRNOT00000086259.3
    Conserved Domains (2) summary
    cd06257
    Location:886 → 931
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam10409
    Location:251 → 389
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  4. XM_006238449.5 → XP_006238511.1  putative tyrosine-protein phosphatase auxilin isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZWX0
    Related
    ENSRNOP00000084012.2, ENSRNOT00000116178.2
    Conserved Domains (4) summary
    cd06257
    Location:848 → 893
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    PHA03247
    Location:521 → 752
    PHA03247; large tegument protein UL36; Provisional
    cd14563
    Location:43 → 205
    PTP_auxilin_N; N-terminal protein tyrosine phosphatase-like domain of auxilin
    pfam10409
    Location:213 → 351
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107949.5: Suppressed sequence

    Description
    NM_001107949.5: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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