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Mier1 MIER1 transcriptional regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 313418, updated on 2-Nov-2024

Summary

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Official Symbol
Mier1provided by RGD
Official Full Name
MIER1 transcriptional regulatorprovided by RGD
Primary source
RGD:1562337
See related
EnsemblRapid:ENSRNOG00000007175 AllianceGenome:RGD:1562337
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562337
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in chromatin remodeling; negative regulation of transcription by RNA polymerase II; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Orthologous to human MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 259.3), Spleen (RPKM 156.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mier1 in Genome Data Viewer
Location:
5q33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (123105114..123156653)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (117876012..117927592)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (122642065..122693642)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene insulin like 5 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene solute carrier family 35 member D1 Neighboring gene similar to human chromosome 1 open reading frame 141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188399

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mesoderm induction early response protein 1
Names
mesoderm induction early response 1 homolog
mesoderm induction early response 1, transcriptional regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131012.1 → NP_001124484.1  mesoderm induction early response protein 1

    See identical proteins and their annotated locations for NP_001124484.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168252
    UniProtKB/TrEMBL
    B4F7F2, E9PT68
    Related
    ENSRNOP00000063001.1, ENSRNOT00000066041.3
    Conserved Domains (3) summary
    smart00717
    Location:288 → 333
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:288 → 332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:182 → 231
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    123105114..123156653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593373.3 → XP_017448862.1  mesoderm induction early response protein 1 isoform X2

    Related
    ENSRNOP00000085059.2, ENSRNOT00000095676.2

  2. XM_017593374.3 → XP_017448863.1  mesoderm induction early response protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A0V9

  3. XM_006238479.4 → XP_006238541.1  mesoderm induction early response protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZWG7
    Related
    ENSRNOP00000081443.2, ENSRNOT00000099770.2
    Conserved Domains (3) summary
    smart00717
    Location:437 → 482
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:437 → 481
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:331 → 380
    ELM2; ELM2 domain

  4. XM_063287698.1 → XP_063143768.1  mesoderm induction early response protein 1 isoform X13

  5. XM_063287696.1 → XP_063143766.1  mesoderm induction early response protein 1 isoform X11

  6. XM_039109957.2 → XP_038965885.1  mesoderm induction early response protein 1 isoform X5

    UniProtKB/TrEMBL
    E9PT68
    Conserved Domains (2) summary
    cd11661
    Location:287 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181 → 230
    ELM2; ELM2 domain

  7. XM_017593381.3 → XP_017448870.1  mesoderm induction early response protein 1 isoform X1

    UniProtKB/TrEMBL
    E9PT68
    Conserved Domains (2) summary
    cd11661
    Location:324 → 368
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:218 → 267
    ELM2; ELM2 domain

  8. XM_039109952.2 → XP_038965880.1  mesoderm induction early response protein 1 isoform X3

    UniProtKB/TrEMBL
    E9PT68
    Conserved Domains (2) summary
    cd11661
    Location:311 → 355
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:205 → 254
    ELM2; ELM2 domain

  9. XM_063287693.1 → XP_063143763.1  mesoderm induction early response protein 1 isoform X7

  10. XM_063287694.1 → XP_063143764.1  mesoderm induction early response protein 1 isoform X8

  11. XM_063287697.1 → XP_063143767.1  mesoderm induction early response protein 1 isoform X12

  12. XM_039109951.2 → XP_038965879.1  mesoderm induction early response protein 1 isoform X9

    UniProtKB/TrEMBL
    E9PT68
    Conserved Domains (2) summary
    cd11661
    Location:321 → 365
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:215 → 264
    ELM2; ELM2 domain

  13. XM_063287695.1 → XP_063143765.1  mesoderm induction early response protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZSL3, A6JRS4

  14. XM_039109948.2 → XP_038965876.1  mesoderm induction early response protein 1 isoform X1

    UniProtKB/TrEMBL
    E9PT68
    Conserved Domains (2) summary
    cd11661
    Location:324 → 368
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:218 → 267
    ELM2; ELM2 domain

  15. XM_039109956.2 → XP_038965884.1  mesoderm induction early response protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZSL3, A6JRS4, E9PT68
    Conserved Domains (2) summary
    cd11661
    Location:305 → 349
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:199 → 248
    ELM2; ELM2 domain

  16. XM_063287701.1 → XP_063143771.1  mesoderm induction early response protein 1 isoform X15

  17. XM_063287700.1 → XP_063143770.1  mesoderm induction early response protein 1 isoform X5

  18. XM_063287703.1 → XP_063143773.1  mesoderm induction early response protein 1 isoform X17

  19. XM_063287699.1 → XP_063143769.1  mesoderm induction early response protein 1 isoform X14

  20. XM_063287702.1 → XP_063143772.1  mesoderm induction early response protein 1 isoform X16

Nucleotide Protein Strain
Heading Accession and Version

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